Department of Internal Medicine, Laboratory of Nutrigenomics Studies, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil -
Departament of Nutrition, University of Franca, Franca, Brazil -
J Sports Med Phys Fitness. 2021 Dec;61(12):1605-1612. doi: 10.23736/S0022-4707.20.11946-7. Epub 2020 Dec 11.
Beta-alanine has become a dietary supplement widely used by athletes due to its ergogenic effect. However, there is still no consensus on the performance benefit of beta-alanine on exercise lasting longer than ten minutes. The present study aimed to evaluate the effect of beta-alanine supplementation on running performance and the expression of TauT and PAT1.
This double-blind, randomized study enrolled 16 long-distance runners (37±8 years) who were randomly allocated to two groups: placebo (PLA) and beta-alanine (BA) (4.8 g/day 1) for four weeks. Maximal oxygen consumption, anthropometry, body composition, and food intake were determined. Before and after the intervention, the athletes undertook a 5000 m running time trial. Venous blood (TauT and PAT1 expressions) and ear lobe capillary blood (lactate) collected before and after exercise. Between tests, we monitored the training variables.
The results were analyzed by t-tests and an ANOVA of repeated measures, with Sidak's post hoc (P<0.05). PLA exhibited lower body fat than BA (8.7±2.2 vs. 11.5±2.8%, P=0.04). After supplementation, there was an increase in PAT1 expression in BA when compared to PLA (1.17±0.47 vs. 0.77±0.18, P=0.04). No significant differences were shown for the 5000 m running time in PLA (PRE: 1128±72; POST: 1123±72s) and BA (PRE: 1107±95; POST: 1093±86s).
Although beta-alanine supplementation increased PAT1 expression, there was no statistically significant improvement in 5000 m running performance. However, individual responses should be considered as the BA showed a higher delta than the PLA.
由于具有促进运动表现的作用，β-丙氨酸已成为运动员广泛使用的膳食补充剂。然而，对于β-丙氨酸在持续时间超过十分钟的运动中的表现益处，目前仍未达成共识。本研究旨在评估β-丙氨酸补充对跑步表现和 TauT 和 PAT1 表达的影响。
这是一项双盲、随机研究，共纳入 16 名长跑运动员（37±8 岁），他们被随机分为两组：安慰剂（PLA）和β-丙氨酸（BA）（4.8 g/天，持续四周）。测定最大摄氧量、人体测量学、身体成分和食物摄入量。干预前后，运动员进行 5000 米跑步计时赛。运动前后采集静脉血（TauT 和 PAT1 表达）和耳垂毛细血管血（乳酸）。在测试之间，我们监测了训练变量。
通过 t 检验和重复测量方差分析进行数据分析， Sidak 事后检验（P<0.05）。PLA 的体脂比 BA 低（8.7±2.2 对 11.5±2.8%，P=0.04）。补充后，BA 的 PAT1 表达比 PLA 增加（1.17±0.47 对 0.77±0.18，P=0.04）。PLA（PRE：1128±72；POST：1123±72s）和 BA（PRE：1107±95；POST：1093±86s）的 5000 米跑步时间均无显著差异。
尽管β-丙氨酸补充提高了 PAT1 表达，但 5000 米跑步表现并无统计学意义上的改善。然而，应该考虑个体反应，因为 BA 的增量比 PLA 高。
