Xiangya Nursing School, Central South University, Changsha, China.
Third Xiangya Hospital, Central South University, Changsha, China.
Psychol Health Med. 2021 Oct;26(9):1154-1162. doi: 10.1080/13548506.2020.1859560. Epub 2020 Dec 11.
Depression is a common psychological problem in kidney transplantation (KT) recipients and affects long-term graft outcomes. Estimated glomerular filtration rate (eGFR) as a commonly used indicator of renal function plays a vital role in follow-up detection after KT. The aim of this study is to observe the change of early eGFR within 3 months after KT and to explore the correlation between eGFR and depression before and after transplantation. The Self-rating Depression Scale was used to evaluate depression. Among 135 patients with KT, 128 patients completed the longitudinal study. We used a one-way repeated-measures analysis of variance to analyze eGFR and a generalized estimating equation model to examine the relationship between depression and eGFR in KT recipients with pre-transplant and 30, 60, 90 days post-transplant. The mean eGFR of KT recipients at four time-points was 5.97 ± 4.83, 72.84 ± 26.06, 79.06 ± 26.45 and 81.79 ± 25.62, respectively. The results demonstrated that eGFR kept steady at 60 days and 90 days post-transplant; depression was significantly associated with eGFR. Earlier identification and treatment of depression in KT recipients may be essential to promote their recovery of early renal function.
抑郁症是肾移植（KT）受者中常见的心理问题，会影响长期移植物的结局。估计肾小球滤过率（eGFR）作为肾功能的常用指标，在 KT 后随访检测中起着至关重要的作用。本研究旨在观察 KT 后 3 个月内早期 eGFR 的变化，并探讨 eGFR 与移植前后抑郁的相关性。采用自评抑郁量表（SDS）评估抑郁情况。在 135 例 KT 患者中，有 128 例完成了纵向研究。我们采用单向重复测量方差分析来分析 eGFR，并采用广义估计方程模型来检验移植前和移植后 30、60、90 天的 KT 受者中抑郁与 eGFR 之间的关系。4 个时间点 KT 受者的平均 eGFR 分别为 5.97±4.83、72.84±26.06、79.06±26.45 和 81.79±25.62。结果表明，eGFR 在移植后 60 天和 90 天保持稳定；抑郁与 eGFR 显著相关。早期识别和治疗 KT 受者的抑郁可能对促进其早期肾功能恢复至关重要。
