Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, Arizona 85721, United States.
Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
Org Lett. 2021 Jan 1;23(1):107-112. doi: 10.1021/acs.orglett.0c03785. Epub 2020 Dec 11.
A 5- trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.
由苄胺衍生的 Ugi 三组分反应产物的 5-三氧化自由基环化反应迅速提供具有三个多样性元素的咪唑烷酮。这种对我们之前描述的多组分反应-氧化方法的改编进一步展示了通过氧化自由基环化来操纵多组分反应产物中的多样性元素，从而生成高度修饰的特权杂环。
