Department of Medicine, University of Louisville Alcohol Research Center, Louisville, Kentucky, USA.
Department of Pharmacology & Toxicology, University of Louisville Alcohol Research Center, Louisville, Kentucky, USA.
Am J Gastroenterol. 2021 Jan 1;116(1):77-79. doi: 10.14309/ajg.0000000000001042.
It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree.
有时仍然难以将酒精相关性肝炎 (AH) 与其他肝脏问题区分开来。在 AJG 的这一版中，Atkinson 等人表明，角蛋白-18（中间丝蛋白）是预测 AH 组织学严重程度、定义肝细胞死亡类型（坏死与凋亡）、预测 90 天死亡率以及预测严重 AH 对皮质类固醇治疗反应的有前途的生物标志物。作者得出结论，K18 具有诊断、预后作用，并且可能是预测泼尼松龙治疗的治疗性标志物，并指出“应将血清 K18 评估纳入常规临床实践”。我们同意。
