Pamukkale University, Faculty of Medicine, Department of Nuclear Medicine, Denizli, Turkey.
Hell J Nucl Med. 2020 Sep-Dec;23(3):296-303. doi: 10.1967/s002449912208. Epub 2020 Dec 14.
Acute appendicitis (AA) is a common urgent surgical situation of the gastrointestinal tract. Gallium-68 (Ga)-citrate has been recently investigated as a radiopharmaceutical for infection and inflammation imaging. Aim of the study was to determine the effectiveness of Ga-citrate positron emission tomography/computed tomography (PET/CT) imaging in rabbits with experimentally induced AA.
In the AA group (n=6), the appendices of the rabbits were surgically ligated. The sham group (n=6) was used as control. Gallium-68-citrate was synthesized. All rabbits were imaged using Ga-citrate PET/CT at 36 following the establishment of experimental models, and at 36 h, all rabbits were appendectomised. Appendices were examined histopathologically. Blood samples were drawn from all rabbits at the beginning and end of the experimental process. Interleukin-6 (IL-6) and procalcitonin (Pct) levels were measured. Acute appendicitis was confirmed histopathologically and biochemically.
Gallium-68-citrate PET/CT showed acute appendicitis in all rabbits. The sensitivity, specificity and accuracy of Ga-citrate PET/CT in AA were 100%, 83.3% and 91.7%, respectively.
Acute appendicitis is accurately imaged in an experimental rabbit model by using Ga-citrate with PET/CT.
急性阑尾炎（AA）是一种常见的胃肠道紧急外科情况。镓-68（Ga）-柠檬酸盐最近已被研究作为感染和炎症成像的放射性药物。本研究的目的是确定镓-柠檬酸盐正电子发射断层扫描/计算机断层扫描（PET/CT）成像在实验性诱导 AA 的兔中的有效性。
在 AA 组（n=6）中，兔的阑尾被手术结扎。假手术组（n=6）用作对照。合成了镓-68 柠檬酸盐。在建立实验模型后 36 小时，所有兔子均使用 Ga-citrate PET/CT 进行成像，在 36 小时时，所有兔子均进行阑尾切除术。对阑尾进行组织病理学检查。在实验过程开始和结束时，从所有兔子中抽取血液样本。测量白细胞介素-6（IL-6）和降钙素原（Pct）水平。通过组织病理学和生物化学证实急性阑尾炎。
镓-68 柠檬酸盐 PET/CT 显示所有兔子均患有急性阑尾炎。Ga-citrate PET/CT 对 AA 的敏感性、特异性和准确性分别为 100%、83.3%和 91.7%。
使用 Ga-citrate 进行 PET/CT 可准确地在实验兔模型中成像急性阑尾炎。
