From the Department of Pediatric Hematology and Oncology, King Fahad Medical City, Riyadh, Saudi Arabia.
From the Department of Pathology and Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.
Ann Saudi Med. 2020 Nov-Dec;40(6):482-490. doi: 10.5144/0256-4947.2020.482. Epub 2020 Dec 3.
There is limited data from Saudi Arabia on the demographic characteristics, outcomes and effectiveness of different treatment modalities in children with intracranial ependymoma.
Study the characteristics of pediatric ependymoma and outcomes of treatment modalities in Saudi Arabia.
Retrospective.
Tertiary care center.
Children with intracranial ependymoma who were younger than 14 years of age and treated between 2006 and 2015 were included in the study. Patients with prior radiation, chemo-therapy, or surgical resection at other centers were excluded.
Kaplan-Meier survival curves were used to estimate the event-free (EFS) and overall survival (OS) rates of the patients.
Of the 22 children, 4 (18.2%) were less than three years old. All intracranial ependymomas had upfront surgical resection of the primary tumor. Gross total resection was achievable in 9 (42.9%) cases and subtotal resection in another 9 (42.9%). Near-total resection was done in 3 (14.3%) cases. Median time from surgery to start of radiotherapy was 62 days. RT was given to 17 (77.3%) patients. Both mean and median RT dose was 55.8 Gy. Only 5 (22.7%) of the children received chemotherapy. The median duration of follow-up was 5.38 years and the median time for EFS was 2.27 years. The cumulative OS rate of the study was 44.5%. The cumulative EFS survival rate of the study was 18.6%. Among demographic, pathological, radiological features, none had a statistically significant effect on the survival.
The outcomes are comparable to those reported by international investigators for similar populations. Further improvements can be achieved by avoiding delays in radiation therapy and adding molecular staging.
The limited number of cases, retrospective nature, lack of molecular biology and size of the tumors.
None.
沙特阿拉伯关于颅内室管膜瘤的患者人口统计学特征、治疗结果和不同治疗方式的有效性的数据有限。
研究沙特阿拉伯小儿室管膜瘤的特征及不同治疗方式的结果。
回顾性。
三级医疗中心。
纳入年龄小于 14 岁且于 2006 年至 2015 年间在本中心接受治疗的颅内室管膜瘤患儿。排除曾在其他中心接受过放疗、化疗或手术切除的患者。
采用 Kaplan-Meier 生存曲线估计患者的无事件生存（EFS）和总生存（OS）率。
22。
22 名患儿中，4 名（18.2%）年龄小于 3 岁。所有颅内室管膜瘤患儿均行原发性肿瘤的初始手术切除。9 例（42.9%）实现了大体全切除，9 例（42.9%）实现了次全切除，3 例（14.3%）实现了近全切除。术后至开始放疗的中位时间为 62 天。17 例（77.3%）患儿接受了放疗。平均和中位放疗剂量分别为 55.8 Gy。仅有 5 例（22.7%）患儿接受了化疗。中位随访时间为 5.38 年，中位 EFS 时间为 2.27 年。本研究的累积 OS 率为 44.5%。本研究的累积 EFS 生存率为 18.6%。在人口统计学、病理学、影像学特征中，均无一项对生存有统计学意义的影响。
本研究结果与国际研究者报告的类似人群相似。通过避免放疗延迟和增加分子分期，可进一步改善预后。
病例数量有限、回顾性研究、缺乏分子生物学和肿瘤大小。
无。
