胎儿生长受限的母体和胎盘锌铜状况。
Maternal and Placental Zinc and Copper Status in Intra-Uterine Growth Restriction.
机构信息
Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey.
Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara University, Ankara, Turkey.
出版信息
Fetal Pediatr Pathol. 2022 Feb;41(1):107-115. doi: 10.1080/15513815.2020.1857484. Epub 2020 Dec 12.
BACKGROUND AND AIM
Zinc and copper are essential trace elements for cell growth and proliferation. Their deficiency may contribute to intrauterine growth restriction (IUGR). We aimed to determine the zinc and copper status of maternal serum and placenta samples of pregnant women with fetal IUGR and age-matched pregnant women without IUGR.
METHOD
Serum and placenta samples obtained from 37 IUGR and 21 healthy pregnant women were analyzed at delivery.
RESULTS
Placenta zinc concentrations and placenta zinc/copper ratio were significantly lower in the IUGR group compared to controls (p < 0.05). Placenta zinc concentrations correlated with birth weight (p: 0.01, r: 0.31). Maternal levels of zinc and copper were similar between pregnant women with IUGR and controls.
CONCLUSIONS
Lower placental zinc and zinc/copper ratio levels in pregnancies with IUGR may indicate that placenta zinc and placental zinc/copper status might be involved in IUGR.
背景与目的
锌和铜是细胞生长和增殖所必需的微量元素。它们的缺乏可能导致宫内生长受限（IUGR）。我们旨在确定胎儿 IUGR 孕妇和年龄匹配的无 IUGR 孕妇的母血清和胎盘样本中的锌和铜状况。
方法
在分娩时分析了 37 例 IUGR 和 21 例健康孕妇的血清和胎盘样本。
结果
与对照组相比，IUGR 组胎盘锌浓度和胎盘锌/铜比值显著降低（p<0.05）。胎盘锌浓度与出生体重相关（p：0.01，r：0.31）。IUGR 孕妇与对照组的母体锌和铜水平相似。
结论
IUGR 妊娠中胎盘锌和锌/铜比值较低可能表明胎盘锌和胎盘锌/铜状态可能与 IUGR 有关。
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