Peng Tongyu, Liu Chenglin, Qian Yuanmin
The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Chongqing Medical University, Chongqing, 400016, China.
J Assist Reprod Genet. 2025 Mar;42(3):707-720. doi: 10.1007/s10815-024-03375-4. Epub 2025 Jan 10.
Pregnancy complications pose challenges for both pregnant women and obstetricians globally, with the pathogenesis of many remaining poorly understood. Recently coined as a mode of cell death, cuproptosis has been proposed but remains largely unexplored. This process involves copper overload, resulting in the accumulation of fatty acylated proteins and subsequent loss of iron-sulfur cluster proteins. This cascade induces proteotoxic stress, leading to cell death. In recent years, studies have indicated a connection between abnormal copper metabolism and several pregnancy-related diseases, including maternal placental dysplasia, gestational diabetes mellitus (GDM), gestational hypertension (PIH), preterm birth or abortion, as well as conditions in offspring such as intrauterine growth restriction (IUGR), allergic disease, Menkes disease, and Wilson's disease. Investigating the mechanism of cuproptosis and abnormal copper metabolism in these pregnancy-related diseases emerges as a critical research area. This article provides a concise review of cuproptosis mechanisms and emphasizes the association between abnormal copper metabolism and pregnancy-related diseases. Nevertheless, the doubtful viewpoints were also discussed.
妊娠并发症给全球孕妇和产科医生都带来了挑战，许多并发症的发病机制仍知之甚少。最近提出了一种名为铜死亡的细胞死亡方式，但在很大程度上仍未得到充分探索。这个过程涉及铜过载，导致脂肪酰化蛋白的积累以及随后铁硫簇蛋白的丧失。这种级联反应诱导蛋白毒性应激，导致细胞死亡。近年来，研究表明铜代谢异常与几种妊娠相关疾病之间存在联系，包括母体胎盘发育异常、妊娠期糖尿病（GDM）、妊娠期高血压（PIH）、早产或流产，以及后代的一些病症如宫内生长受限（IUGR）、过敏性疾病、门克斯病和威尔逊病。研究这些妊娠相关疾病中铜死亡和铜代谢异常的机制已成为一个关键的研究领域。本文简要综述了铜死亡机制，并强调了铜代谢异常与妊娠相关疾病之间的关联。然而，也讨论了一些存疑的观点。
