American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
Lancet. 2021 Jan 23;397(10271):319-333. doi: 10.1016/S0140-6736(20)32667-2. Epub 2020 Dec 10.
It is estimated that infertility affects 8-12% of couples globally, with a male factor being a primary or contributing cause in approximately 50% of couples. Causes of male subfertility vary highly, but can be related to congenital, acquired, or idiopathic factors that impair spermatogenesis. Many health conditions can affect male fertility, which underscores the need for a thorough evaluation of patients to identify treatable or reversible lifestyle factors or medical conditions. Although semen analysis remains the cornerstone for evaluating male infertility, advanced diagnostic tests to investigate sperm quality and function have been developed to improve diagnosis and management. The use of assisted reproductive techniques has also substantially improved the ability of couples with infertility to have biological children. This Seminar aims to provide a comprehensive overview of the assessment and management of men with infertility, along with current controversies and future endeavours.
据估计，不孕不育影响全球 8-12%的夫妇，其中约 50%的夫妇存在男性因素为主或作为促成因素。男性不育的原因多种多样，但可能与先天性、后天性或特发性因素有关，这些因素会损害精子发生。许多健康状况会影响男性生育能力，这凸显出需要对患者进行全面评估，以确定可治疗或可逆转的生活方式因素或医疗状况。尽管精液分析仍然是评估男性不育的基石，但已经开发出了更先进的诊断测试来研究精子质量和功能，以改善诊断和管理。辅助生殖技术的应用也极大地提高了不孕不育夫妇拥有亲生子女的能力。本次研讨会旨在全面概述男性不育的评估和管理，以及当前的争议和未来的努力。
