Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; The George Institute for Global Health, University of Oxford, Oxford, UK.
Maturitas. 2021 Jan;143:81-88. doi: 10.1016/j.maturitas.2020.09.008. Epub 2020 Oct 1.
To examine the associations of childhood adiposity with menopausal symptoms in women aged 45-49 years.
National population-based cohort study of 334 girls prospectively followed from childhood (aged 11-15) through to midlife (aged 45-49). Childhood overweight and obesity were defined by international age- and sex-specific standards for body mass index (BMI), and abdominal obesity was defined as waist/height ratio≥0.5.
Vasomotor symptoms (VMS), vaginal dryness, total menopausal symptoms and domain-specific symptoms (somatic, psychological and urogenital) were measured during 2018-19 using the Menopause Rating Scale (MRS) and classified as none, mild, moderate or severe.
The prevalence of mild, moderate and severe VMS was 24.0 %, 9.0 % and 3.9 %, and of vaginal dryness was 12.6 %, 4.8 % and 2.4 %. No significant associations of childhood overweight/obesity or abdominal obesity with VMS or vaginal dryness were found after adjustment for childhood age, follow-up length, smoking, socioeconomic status and diet quality. Childhood overweight/obesity was associated with increased risks of more severe total (RR:1.17, 95 % CI:1.02-1.36), psychological (RR:1.19, 95 % CI:1.04-1.35) and urogenital (RR:1.29, 95 % CI:1.14-1.46) symptoms measured using the MRS. Associations with childhood abdominal obesity were mostly stronger with more severe total (RR:2.19, 95 % CI:1.48-3.23), somatic (RR:1.52, 95 % CI:1.15-2.02), psychological (RR:1.21, 95 % CI:1.04-1.42) and urogenital (RR:2.11, 95 % CI:1.39-3.20) symptoms.
Childhood adiposity was not associated with increased risks of more severe VMS or vaginal dryness in women aged 45-49 years. Childhood adiposity, especially abdominal obesity, was associated with more severe total, somatic, psychological and urogenital symptoms. However, the association between these symptoms and menopause is not established.
研究 45-49 岁女性儿童期肥胖与绝经症状的关系。
这是一项全国性的队列研究，共纳入 334 名女孩，从儿童期（11-15 岁）开始进行前瞻性随访，直至中年（45-49 岁）。采用国际年龄和性别特定的 BMI 标准来定义儿童期超重和肥胖，腰围/身高比≥0.5 定义为腹型肥胖。
使用绝经评定量表（MRS）在 2018-19 年期间测量血管舒缩症状（VMS）、阴道干燥、总绝经症状和特定领域症状（躯体、心理和泌尿生殖），并分为无、轻度、中度或重度。
轻度、中度和重度 VMS 的患病率分别为 24.0%、9.0%和 3.9%，阴道干燥的患病率分别为 12.6%、4.8%和 2.4%。调整儿童期年龄、随访时间、吸烟、社会经济地位和饮食质量后，儿童期超重/肥胖或腹型肥胖与 VMS 或阴道干燥之间无显著相关性。儿童期超重/肥胖与 MRS 测量的更严重的总症状（RR：1.17，95%CI：1.02-1.36）、心理症状（RR：1.19，95%CI：1.04-1.35）和泌尿生殖症状（RR：1.29，95%CI：1.14-1.46）风险增加相关。与儿童期腹型肥胖相关的关联在更严重的总症状（RR：2.19，95%CI：1.48-3.23）、躯体症状（RR：1.52，95%CI：1.15-2.02）、心理症状（RR：1.21，95%CI：1.04-1.42）和泌尿生殖症状（RR：2.11，95%CI：1.39-3.20）方面更为强烈。
儿童期肥胖与 45-49 岁女性更严重的 VMS 或阴道干燥风险增加无关。儿童期肥胖，尤其是腹型肥胖，与更严重的总症状、躯体症状、心理症状和泌尿生殖症状有关。然而，这些症状与绝经之间的关联尚未确定。
