Department of Gastroenterology and Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Gastroenterology and Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Clin Biochem. 2021 Mar;89:44-50. doi: 10.1016/j.clinbiochem.2020.12.005. Epub 2020 Dec 10.
The study compared the diagnostic efficiency of serum oligosaccharide chain (G-test) and alpha-fetoprotein (AFP) for hepatitis B-related hepatocellular carcinoma (HCC).
Serum samples from 100 patients (divided into five groups of 20 each, namely the hepatitis, liver cirrhosis, liver cancer, health, and interference groups) who were admitted to the Second Affiliated Hospital of Nanchang University from October 2019 to January 2020 were collected, and the levels of G-test and AFP were determined. The sensitivity and specificity of the two indicators were compared, and the receiver operating characteristic curve of the subjects was drawn to evaluate the diagnostic values of G-test and AFP for HCC.
The diagnostic ability of G-test (area under the curve [AUC]: 0.88 ± 0.05) was better than that of AFP (AUC: 0.76 ± 0.05). When G-test and AFP were combined for detection, the AUC was larger than that of either indicator. The G-test was superior to AFP in the differential diagnosis of early HCC and cirrhosis. A combination of the two indicators (AUC: 0.769 ± 0.05) significantly improved the diagnostic rate for early HCC, indicating that G-test and AFP complemented each other.
G-test was better than AFP for screening HCC in patients with chronic hepatitis B and cirrhosis. The combination of the two further improved the diagnostic rate of hepatitis B-related liver cancer. The G-test improves the screening rate of early HCC in patients with cirrhosis. Therefore, these markers are of great clinical significance and can improve the sensitivity of HCC detection and reduce missed diagnosis rates.
本研究比较了血清寡糖链（G 试验）和甲胎蛋白（AFP）对乙型肝炎相关肝细胞癌（HCC）的诊断效率。
收集 2019 年 10 月至 2020 年 1 月南昌大学第二附属医院收治的 100 例患者（分为肝炎、肝硬化、肝癌、健康和干扰 5 组，每组 20 例）的血清样本，检测 G 试验和 AFP 水平。比较两种指标的灵敏度和特异性，绘制受试者工作特征曲线，评价 G 试验和 AFP 对 HCC 的诊断价值。
G 试验（曲线下面积 [AUC]：0.88±0.05）的诊断能力优于 AFP（AUC：0.76±0.05）。当联合检测 G 试验和 AFP 时，AUC 大于任一指标。G 试验在早期 HCC 和肝硬化的鉴别诊断中优于 AFP。两项指标联合检测（AUC：0.769±0.05）可显著提高早期 HCC 的诊断率，表明 G 试验和 AFP 互为补充。
G 试验优于 AFP 用于筛查慢性乙型肝炎和肝硬化患者的 HCC。两种标志物联合使用进一步提高了乙型肝炎相关肝癌的诊断率。G 试验提高了肝硬化患者早期 HCC 的筛查率。因此，这些标志物具有重要的临床意义，可以提高 HCC 检测的灵敏度，降低漏诊率。
