Lu Ke, Yu Muyuan, Chen Yongchang
Department of Urology, Changshu Second People's Hospital, Yangzhou University Fifth Clinical Medical College, Changshu, China.
Department of Urology, Changshu Second People's Hospital, Yangzhou University Fifth Clinical Medical College, Changshu, China.
Clin Chim Acta. 2021 Feb;513:57-63. doi: 10.1016/j.cca.2020.11.027. Epub 2020 Dec 10.
Prostate cancer (PCa) is one of the most common malignancies for men worldwide, and abnormal activation of the androgen receptor (AR) signaling plays an important role in the progression of PCa. However, in the androgen deprivation therapy (ADT), AR signaling inevitably recovered, as a result, exploring novel regulating mechanisms is of great importance. Recently, non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, circular RNAs, could be involved in the progression of PCa, and participate in the regulatory network of AR signaling in a variety of ways. This will help to identify novel molecular mechanisms to promote the development of PCa and find new potential therapeutic targets. In this review, we provide a synopsis of the latest research relating to ncRNAs and associated AR signaling in PCa.
前列腺癌（PCa）是全球男性中最常见的恶性肿瘤之一，雄激素受体（AR）信号通路的异常激活在PCa的进展中起重要作用。然而，在雄激素剥夺疗法（ADT）中，AR信号通路不可避免地会恢复，因此，探索新的调控机制至关重要。最近，非编码RNA（ncRNAs），包括微小RNA、长链非编码RNA、环状RNA，可能参与PCa的进展，并以多种方式参与AR信号通路的调控网络。这将有助于识别促进PCa发展的新分子机制，并找到新的潜在治疗靶点。在本综述中，我们概述了PCa中与ncRNAs及相关AR信号通路的最新研究。
