Jueng C, Halperin A K, Hashimoto F, Callender K
Veterans Administration Medical Center, Albuquerque, New Mexico 87108.
J Clin Hypertens. 1987 Dec;3(4):695-703.
Twenty-nine subjects with mild to moderate essential hypertension completed this 13 week randomized, double-blind, placebo-controlled study comparing the antihypertensive effects of nifedipine GITS (N) (30-60 mg/day), hydrochlorothiazide (H) (25-50 mg/day) and placebo (P). Nifedipine GITS is a new formulation designed for once daily administration. N lowered blood pressure 15/10 mmHg (p less than 0.0005/p less than 0.0001), H 15/8 mmHg (p less than 0.0005/p 0.05), and P 4/0 mmHg (p = NS). All patients required the larger dose of active drug to control BP. No drug affected the heart rate. For N, but not H, there was a positive correlation between age and the magnitude in reduction of SBP (r = 0.79; p less than 0.005), but not for DPB. N drug levels did not correlate with its antihypertensive effect. Epinephrine, norepinephrine, aldosterone, and plasma renin activity were not affected by N. No patients on N experienced immediate vasodilator side effects. N is a well tolerated and effective antihypertensive drug that can be given once daily. It does not cause reflex stimulation of the sympathetic nervous system.
29名轻至中度原发性高血压患者完成了这项为期13周的随机、双盲、安慰剂对照研究，比较了硝苯地平控释片（N）（30 - 60毫克/天）、氢氯噻嗪（H）（25 - 50毫克/天）和安慰剂（P）的降压效果。硝苯地平控释片是一种设计用于每日一次给药的新剂型。N使血压降低15/10毫米汞柱（p < 0.0005/p < 0.0001），H使血压降低15/8毫米汞柱（p < 0.0005/p = 0.05），P使血压降低4/0毫米汞柱（p = 无统计学意义）。所有患者都需要较大剂量的活性药物来控制血压。没有药物影响心率。对于N，而非H，年龄与收缩压降低幅度之间存在正相关（r = 0.79；p < 0.005），但舒张压不存在这种相关性。N的药物水平与其降压效果不相关。肾上腺素、去甲肾上腺素、醛固酮和血浆肾素活性不受N的影响。服用N的患者未出现即刻血管扩张副作用。N是一种耐受性良好且有效的降压药物，可每日给药一次。它不会引起交感神经系统的反射性刺激。
