Heart Research Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, Faculty of Medicine, University of Melbourne, Melbourne, Australia.
Division of Cardiac Surgery, Children's National Hospital, Washington, DC.
Ann Thorac Surg. 2021 Nov;112(5):1698-1706. doi: 10.1016/j.athoracsur.2020.10.054. Epub 2020 Dec 11.
There is an increasing prevalence of chronic kidney disease in the population of adults currently living with congenital heart disease. A considerable proportion of children who undergo congenital heart surgery experience postoperative acute kidney injury. Whether there is an association between acute kidney injury after cardiac surgery in childhood and development of chronic kidney disease is unclear.
Three electronic databases were searched to capture relevant studies exploring the relationship between acute kidney injury after congenital heart surgery in children and progression to chronic kidney disease.
A literature search identified a total of 212 research articles, 7 of which were selected for in-depth review.
There is a likely association between acute kidney injury in children undergoing congenital heart surgery and progression to chronic kidney disease. Research should be developed to mitigate factors contributing to postoperative acute kidney injury in neonates, infants, and children undergoing cardiac surgery. Better targeted follow-up protocols to monitor renal function in children undergoing cardiac surgery should be implemented. A universal definition for acute kidney injury and chronic kidney disease is needed to improve detection and research in this field.
目前，患有先天性心脏病的成年人中慢性肾脏病的发病率不断上升。相当一部分接受先天性心脏手术的儿童术后会发生急性肾损伤。儿童心脏手术后急性肾损伤是否与慢性肾脏病的发展有关尚不清楚。
通过 3 个电子数据库搜索了探索儿童先天性心脏病手术后急性肾损伤与慢性肾脏病进展之间关系的相关研究。
文献检索共发现 212 篇研究文章，其中 7 篇被选作深入审查。
儿童先天性心脏病手术后急性肾损伤与慢性肾脏病进展之间可能存在关联。应开展研究，减轻新生儿、婴儿和儿童心脏手术术后急性肾损伤的相关因素。应实施更好的靶向随访方案，以监测接受心脏手术的儿童的肾功能。需要一个急性肾损伤和慢性肾脏病的通用定义，以提高该领域的检测和研究水平。
