Dokuz Eylul University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey; Dokuz Eylul University, Institute of Neuroscience, Izmir, Turkey; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne.
Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey.
J Affect Disord. 2021 Feb 15;281:109-116. doi: 10.1016/j.jad.2020.11.122. Epub 2020 Dec 1.
Bipolar disorder (BD) might be associated in disturbances in brain networks. However, little is known about the abnormalities in structural brain connectivity which might be related to vulnerability to BD and predictive of the emergence of manic symptoms. No previous study has investigated the effect of subthreshold syndromes on structural dysconnectivity in offspring of parents with BD (BDoff).
We investigated diffusion weighted images of 70 BDoff and 48 healthy controls (HC). Nineteen of the 70 BDoff had presented with subthreshold syndromes indicating a clinical high-risk (BDoff-CHR) and other 51 BDoff had no such history (BDoff-non-CHR). Global and regional network properties, rich club organization and inter-regional connectivity in BDoff and healthy controls were investigated using graph analytical methods and network-based-statistics (NBS).
Global properties of WM networks appeared to be intact in BDoff-CHR and BDoff-non-CHR. However, decreased regional connectivity in right occipito-parietal areas and cerebellum was a common feature of both BDoff groups. Importantly, decreased interregional connectivity between nodes in right and left prefrontal regions, nodes in right prefrontal lobe and right temporal lobe and nodes in left occipital area and left cerebellum were evident in BDoff-CHR but not BDoff-non-CHR.
The cross-sectional nature of the study was the main consideration.
Decreased regional connectivity in right posterior brain regions might be related to vulnerability to BD. On the other hand, interregional dysconnectivity in anterior frontal and limbic regions and left posterior brain regions might be evident in individuals genetically at risk for developing BD who had experienced subthreshold mood symptoms.
双相障碍（BD）可能与大脑网络的紊乱有关。然而，人们对结构脑连接的异常知之甚少，这些异常可能与易患 BD 有关，并能预测躁狂症状的出现。以前没有研究调查亚临床综合征对双相障碍父母子女（BDoff）结构连接不良的影响。
我们对 70 名 BDoff 和 48 名健康对照（HC）进行了扩散加权成像研究。70 名 BDoff 中有 19 名出现了亚临床综合征，表明存在临床高风险（BDoff-CHR），而其他 51 名 BDoff 没有这种病史（BDoff-non-CHR）。使用图分析方法和基于网络的统计学（NBS）研究了 BDoff 和健康对照组的全局和区域网络特性、丰富俱乐部组织和区域间连接。
BDoff-CHR 和 BDoff-non-CHR 的 WM 网络全局特性似乎完好无损。然而，右侧枕顶区和小脑的区域连接减少是两个 BDoff 组的共同特征。重要的是，右侧和左侧前额区域之间节点、右侧前额叶和右侧颞叶之间节点以及左侧枕区和左侧小脑之间节点的区域间连接减少在 BDoff-CHR 中明显，而在 BDoff-non-CHR 中不明显。
研究的横断面性质是主要考虑因素。
右侧后脑部的区域连接减少可能与易患 BD 有关。另一方面，在前额和边缘区域以及左后脑部的区域间连接不良可能在经历亚临床情绪症状的具有遗传易感性发展为 BD 的个体中明显。
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