肾活检对肾小球滤过率的影响：患者常关注的问题。
The Effect of Kidney Biopsy on Glomerular Filtration Rate: A Frequent Patient Concern.
作者信息
Dattani Rakesh, Corbett Richard W, Galliford Jack, Hill Peter, Cairns Tom, Cook H Terence, Roufosse Candice, Ashby Damien R
机构信息
Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom,
Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
出版信息
Am J Nephrol. 2020 Dec 11:1-4. doi: 10.1159/000511798.
The effect of percutaneous kidney biopsy on glomerular filtration rate has never been identified, though it is frequently a concern raised by patients. Following a clinical interaction with an inquisitive patient undergoing her fifth biopsy, we attempted to estimate the effect using retrospective data. In a cohort of patients with stable kidney function undergoing transplant biopsy without clinical indication (as part of a surveillance programme) the effect of biopsy was observed as a step change in glomerular filtration rate. Reassuringly, the loss of glomerular filtration rate resulting from a biopsy, has a 1-sided 95% confidence interval of <1.4 mL/min.
经皮肾活检对肾小球滤过率的影响尚未明确，尽管这是患者经常提出的一个担忧。在与一位接受了五次活检的好奇患者进行临床交流后，我们试图利用回顾性数据来评估这种影响。在一组肾功能稳定、无临床指征（作为监测项目的一部分）接受移植肾活检的患者中，观察到活检对肾小球滤过率的影响为阶梯式变化。令人安心的是，活检导致的肾小球滤过率下降，其单侧95%置信区间<1.4 mL/分钟。
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