白细胞介素-6与碳水化合物吸收不良个体的色氨酸代谢及抑郁症状相关。

Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption.

作者信息

Enko Dietmar, Zelzer Sieglinde, Wenninger Julian, Holasek Sandra, Schnedl Wolfgang J, Baranyi Andreas, Herrmann Markus, Meinitzer Andreas

机构信息

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Hochsteiermark, Leoben, Austria.

出版信息

EXCLI J. 2020 Oct 28;19:1414-1422. doi: 10.17179/excli2020-2940. eCollection 2020.

DOI:10.17179/excli2020-2940

PMID:33312105

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7726491/

Abstract

The aim of the present study was to investigate possible associations between interleukin-6 (IL-6), interferon-gamma (INF-γ), tumor necrosis factor-alpha (TNF-α), lactoferrin and lipopolysaccharide binding protein (LBP) with TRP metabolism and signs of depression in a large cohort of outpatients referred for carbohydrate malabsorption testing. Serum concentrations of IL-6, INF-γ, TNF-α, lactoferrin, LBP, tryptophan (TRP), kynurenine (KYN) and kynuric acid were determined in 250 adults referred for lactose and fructose malabsorption testing. All participants filled out the Beck Depression Inventory (BDI). Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, ρ = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, ρ = 0.176 and 0.136). Ninety-five individuals with a BDI score > 13 showed significantly higher IL-6 serum levels (1.7 [1.0 - 2.8] vs. 1.1 [0.8 - 1.7] pg/mL, p < 0.001) compared to 115 individuals with a BDI score ≤ 13. LBP showed a positive correlation with the KYN/TRP ratio (p = 0.005, ρ = 0.177). IL-6 and LBP were associated with indicators of TRP metabolism. IL-6 was found to be linked to signs of depression. Individuals with the presence of depressive symptoms showed higher serum IL-6 levels compared to individuals without depressive symptoms.

摘要

本研究的目的是在一大群因碳水化合物吸收不良检测而转诊的门诊患者中，调查白细胞介素-6（IL-6）、干扰素-γ（INF-γ）、肿瘤坏死因子-α（TNF-α）、乳铁蛋白和脂多糖结合蛋白（LBP）与色氨酸（TRP）代谢及抑郁症状之间可能存在的关联。对250名因乳糖和果糖吸收不良检测而转诊的成年人测定了血清中IL-6、INF-γ、TNF-α、乳铁蛋白、LBP、色氨酸（TRP）、犬尿氨酸（KYN）和犬尿酸的浓度。所有参与者都填写了贝克抑郁量表（BDI）。血清IL-6水平与BDI评分呈正相关（p = 0.001，ρ = 0.205），与TRP代谢指标（KYN/TRP比值、KYN）也呈正相关（P值<0.05，ρ = 0.176和0.136）。与115名BDI评分≤13的个体相比，95名BDI评分>13的个体血清IL-6水平显著更高（1.7[1.0 - 2.8] vs. 1.1[0.8 - 1.7] pg/mL，p < 0.001）。LBP与KYN/TRP比值呈正相关（p = 0.005，ρ = 0.177）。IL-6和LBP与TRP代谢指标相关。发现IL-6与抑郁症状有关。有抑郁症状的个体血清IL-6水平高于无抑郁症状的个体。