Weiner C, Williamson R, Bonsib S M, Erenberg A, Pringle K, Smith W, Abu-Yousef M
Department of Obstetrics and Gynecology, University of Iowa, Iowa City.
Fetal Ther. 1986;1(4):196-202. doi: 10.1159/000262269.
Based upon the concept that an obstruction-maldevelopment sequence is reversible after diversion, it has been suggested that the fetus with a bladder outlet obstruction is a potential candidate for in utero intervention. We report an infant who had both renal and pulmonary dysplasia at birth despite a technically successful diversion at 22 weeks' gestation. The poor outcome suggests that the organ damage either occurs so early that it precludes corrective surgery, or that the maldevelopment is not the result of obstruction, but rather a primary mesodermal defect.
基于梗阻 - 发育不良序列在引流后可逆转的概念，有人提出患有膀胱出口梗阻的胎儿是宫内干预的潜在候选者。我们报告了一名婴儿，尽管在妊娠22周时进行了技术上成功的引流，但出生时仍患有肾和肺发育不良。不良结果表明，器官损伤要么发生得太早以至于无法进行矫正手术，要么发育不良不是梗阻的结果，而是原发性中胚层缺陷。
