UMR 1121, Laboratoire Agronomie et Environnement (LAE), Université de Lorraine- INRAe, Nancy, France.
EA 2106, Biomolécules et biotechnologies végétales (BBV), Université de Tours, Tours, France.
J Exp Bot. 2021 Mar 29;72(7):2334-2355. doi: 10.1093/jxb/eraa582.
Phenolamides represent a family of specialized metabolites, consisting of the association of hydroxycinnamic acid derivatives with aliphatic or aromatic amines. Since the discovery of the first phenolamide in the late 1940s, decades of phytochemical analyses have revealed a high structural diversity for this family and a wide distribution in the plant kingdom. The occurrence of structurally diverse phenolamides in almost all plant organs has led to early hypotheses on their involvement in floral initiation and fertility, as well as plant defense against biotic and abiotic stress. In the present work, we critically review the literature ascribing functional hypotheses to phenolamides and recent evidence on the control of their biosynthesis in response to biotic stress. We additionally provide a phylogenetic analysis of the numerous N-hydroxycinnamoyltransferases involved in the synthesis of phenolamides and discuss the potential role of other enzyme families in their diversification. The data presented suggest multiple evolutionary events that contributed to the extension of the taxonomic distribution and diversity of phenolamides.
苯甲酰胺代表了一类特殊的代谢物，由羟基肉桂酸衍生物与脂肪族或芳香族胺的结合而成。自 20 世纪 40 年代末发现第一种苯甲酰胺以来，几十年的植物化学分析揭示了该家族的高度结构多样性，并在植物界中广泛分布。几乎所有植物器官中结构多样的苯甲酰胺的存在，导致了早期关于它们参与花的起始和生育以及植物对生物和非生物胁迫的防御的假说。在本工作中，我们批判性地回顾了将功能假说归因于苯甲酰胺的文献，并对最近关于生物胁迫下其生物合成控制的证据进行了综述。我们还对参与苯甲酰胺合成的众多 N-羟基肉桂酰转移酶进行了系统发育分析，并讨论了其他酶家族在其多样化中的潜在作用。所提出的数据表明，有多个进化事件有助于苯甲酰胺的分类分布和多样性的扩展。
