Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Unit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Engineering, Università Campus Bio-Medico di Rome, Rome, Italy.
Methods Mol Biol. 2021;2253:77-88. doi: 10.1007/978-1-0716-1154-8_6.
In this paper we report a procedure to analyze protein homodimer interfaces.We approached the problem by means of a topological methodology. In particular, we analyzed the subunits interface of about 50 homodimers and we have defined a few parameters that allow to organize these proteins in six different classes. The main characteristics of each class of homodimers have been discussed also taking into account their stabilization energy, as reported in the literature from the experimental measurements. A paradigmatic example for each class has been reported and a graphical representation proposed in order to better explain the meaning of the parameters chosen.
本文介绍了一种分析蛋白质同源二聚体界面的方法。我们采用拓扑方法来解决这个问题。具体来说，我们分析了大约 50 个同源二聚体的亚基界面，并定义了几个参数，这些参数可以将这些蛋白质分为六个不同的类别。我们还考虑了文献中报道的实验测量得到的稳定能，讨论了每个同源二聚体类别的主要特征。报告了每个类别的一个范例，并提出了一个图形表示，以便更好地解释所选择参数的含义。
