儿童肺结核继发异烟肼所致急性精神病：一例报告及文献综述
Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review.
作者信息
Alfawaz Saleh, Alattas Nadia, Alhammadi Moza, Waqar Saadia, Al Alola Sulaiman
机构信息
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Division of Pediatric Infectious Diseases, King Abdullah Specialized Children's Hospital (KASCH), National Guard Health Affairs, Riyadh, Saudi Arabia.
出版信息
Int J Pediatr Adolesc Med. 2020 Dec;7(4):196-198. doi: 10.1016/j.ijpam.2020.03.012. Epub 2020 Apr 5.
Isoniazid (INH) is a first-line tuberculosis (TB) drug and is currently recommended as part of active and latent TB treatment in all ages. INH adverse reactions range from mild hepatitis to severe neurological symptoms and psychosis. Since its introduction in the 1950s, many case reports have explored INH-induced psychosis. We describe a 12-year-old girl with acute onset hallucinations and delusions as a rare complication of INH and review previous case reports and identified risk factors. Pediatricians need to be aware of this less common side effect as they work through a differential of acute psychosis in children.
异烟肼（INH）是一种一线抗结核药物，目前被推荐用于各年龄段活动性和潜伏性结核病的治疗。异烟肼的不良反应范围从轻度肝炎到严重的神经症状和精神病。自20世纪50年代引入以来，许多病例报告都探讨了异烟肼所致的精神病。我们描述了一名12岁急性起病出现幻觉和妄想的女孩，这是异烟肼罕见的并发症，并回顾了既往病例报告并确定了危险因素。儿科医生在排查儿童急性精神病的鉴别诊断时需要意识到这种不太常见的副作用。
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