Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Cancer Care Center of Maine, Bangor, Maine.
Cancer. 2021 Apr 15;127(8):1208-1219. doi: 10.1002/cncr.33371. Epub 2020 Dec 15.
The objective of this study was to describe the perspective of patients with early breast cancer toward research biopsies. The authors hypothesized that more patients at academic sites than at community-based sites would be willing to consider these procedures.
In total, 198 patients with early stage breast cancer were recruited from 3 academic centers (n = 102) and from 1 community oncology practice (n = 96). The primary objective was to compare the proportion of patients willing to consider donating excess tissue biospecimens from surgery, from a clinically indicated breast biopsy, or from a research purposes-only biopsy (RPOB) between practice types.
Most patients (93% at academic sites, 94% at the community oncology site) said they would consider donating excess tissue from surgery for research. One-half of patients from academic or community sites would consider donating tissue from a clinically indicated breast biopsy. On univariate analysis, significantly fewer patients from academic sites would consider an RPOB (22% at academic sites, 42% at the community site; P = .003); however, this difference was no longer significant on multivariate analysis (P = .96). Longer transportation times and unfavorable prior experiences were associated with less willingness to consider an RPOB on multivariate analysis. Significantly fewer patients from academic sites (14%) than from the community site (35%) would consider a research biopsy in a clinical trial (P = .04). Contributing to scientific knowledge, return of results, and a personal request by their physician were the strongest factors influencing patients' willingness to undergo research biopsies.
The current results rejected the hypothesis that more patients with early breast cancer at academic sites would be willing to donate tissue biospecimens for research compared with those at community oncology sites. These findings identify modifiable factors to consider in biobanking studies and clinical trials.
本研究旨在描述早期乳腺癌患者对研究性活检的看法。作者假设，与社区为基础的医疗场所相比，更多的学术医疗场所的患者愿意考虑进行这些程序。
共有 198 名早期乳腺癌患者从 3 个学术中心（n = 102）和 1 个社区肿瘤学诊所（n = 96）招募。主要目的是比较患者愿意考虑从手术、临床指示性乳房活检或仅为研究目的的活检（RPOB）中捐献多余组织生物样本的比例。
大多数患者（学术医疗场所 93%，社区肿瘤学诊所 94%）表示他们愿意考虑捐献手术中多余的组织用于研究。一半的学术或社区医疗场所的患者会考虑捐献来自临床指示性乳房活检的组织。在单变量分析中，来自学术医疗场所的患者更不愿意考虑 RPOB（学术医疗场所 22%，社区医疗场所 42%；P =.003）；然而，多变量分析时这种差异不再显著（P =.96）。较长的交通时间和不利的先前经历与多变量分析中较少愿意考虑 RPOB 相关。来自学术医疗场所的患者（14%）明显少于来自社区医疗场所的患者（35%）愿意考虑参加临床试验中的研究性活检（P =.04）。对科学知识的贡献、结果的回报以及医生的个人请求是影响患者进行研究性活检意愿的最强因素。
目前的结果否定了这样一种假设，即与社区肿瘤学诊所相比，更多的学术医疗场所的早期乳腺癌患者更愿意捐献组织生物样本进行研究。这些发现确定了在生物库研究和临床试验中需要考虑的可调整因素。
