University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Am Fam Physician. 2020 Dec 15;102(12):740-750.
Degenerative cervical myelopathy encompasses a collection of pathologic conditions that result in progressive spinal cord dysfunction secondary to cord compression. Patients are typically male (3: 1 male-to-female ratio), and the average age of presentation is 64 years. The exact incidence is unclear because of differences in terminology and because radiographic findings can be present in asymptomatic individuals. Common examination findings include neck pain or stiffness, a wide-based ataxic gait, ascending paresthesia in the upper or lower extremities, lower extremity weakness, decreased hand dexterity, hyperreflexia, clonus, Babinski sign, and bowel or bladder dysfunction in severe disease. Definitive diagnosis requires correlation of physical examination findings with imaging findings. Magnetic resonance imaging of the cervical spine with and without contrast media is the preferred imaging modality. Cervical spine computed tomography, computed tomography myelography, and plain radiography are helpful in certain situations. Treatment depends on the presence and severity of symptoms. Surgery is recommended for patients with moderate to severe symptoms or rapidly progressive disease. Conservative treatments with monitoring for progression may be considered in patients with mild to moderate disease. The evidence for the effectiveness of conservative treatments is scarce and of low quality, and outcomes can vary with individual patients. Primary care physicians play a vital role in recognizing the typical presentation of degenerative cervical myelopathy, coordinating treatment as indicated, and managing comorbidities.
退行性颈脊髓病包括一系列病理状况,这些状况导致脊髓功能进行性障碍,继发于脊髓受压。患者通常为男性(男女比例为 3:1),发病的平均年龄为 64 岁。由于术语上的差异以及影像学表现可能出现在无症状个体中,确切的发病率尚不清楚。常见的检查结果包括颈部疼痛或僵硬、基底宽大的共济失调步态、上肢或下肢上升性感觉异常、下肢无力、手部灵活性下降、反射亢进、阵挛、巴宾斯基征以及严重疾病中的肠或膀胱功能障碍。明确诊断需要将体格检查结果与影像学结果相关联。颈椎磁共振成像(MRI)加或不加造影剂是首选的影像学检查方式。在某些情况下,颈椎 CT、CT 脊髓造影和普通 X 线摄影也有帮助。治疗取决于症状的存在和严重程度。对于有中度至重度症状或疾病快速进展的患者,建议手术治疗。对于有轻度至中度疾病的患者,可以考虑采用保守治疗并监测进展。保守治疗的有效性证据稀缺且质量较低,且结果可能因个体患者而异。初级保健医生在识别退行性颈脊髓病的典型表现、根据需要协调治疗以及管理合并症方面发挥着至关重要的作用。
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