Biggins Sue, Hartwell Lee, Toczyski David
Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Biodesign Institute, Arizona State University, Tempe, AZ 85281.
Mol Biol Cell. 2020 Dec 15;31(26):2868-2870. doi: 10.1091/mbc.E20-07-0495.
Fifty years ago, the first isolation of conditional budding yeast mutants that were defective in cell division was reported. Looking back, we now know that the analysis of these mutants revealed the molecular mechanisms and logic of the cell cycle, identified key regulatory enzymes that drive the cell cycle, elucidated structural components that underly essential cell cycle processes, and influenced our thinking about cancer and other diseases. Here, we briefly summarize what was concluded about the coordination of the cell cycle 50 years ago and how that relates to our current understanding of the molecular events that have since been elucidated.
五十年前，首次报道了分离出细胞分裂存在缺陷的条件性出芽酵母突变体。回首往事，我们现在知道，对这些突变体的分析揭示了细胞周期的分子机制和逻辑，确定了驱动细胞周期的关键调节酶，阐明了构成基本细胞周期过程基础的结构成分，并影响了我们对癌症和其他疾病的看法。在这里，我们简要总结一下五十年前关于细胞周期协调得出的结论，以及这与我们目前对此后阐明的分子事件的理解有何关联。
