Nossal R
Physical Sciences Laboratory, DCRT, National Institutes of Health, Bethesda, MD 20892.
Biorheology. 1987;24(6):577-84. doi: 10.3233/bir-1987-24609.
Several noninvasive light scattering techniques are reviewed that can be utilized in rheological studies of mucus and other soft biological matrices. Included are quasielastic light scattering techniques to determine the compressibility moduli of polymer lattices, resonance methods that can be used to measure the shear modulus of weak gels, assays that probe the swelling and contraction of mucin aggregates, and microscope based light scattering techniques to probe gelation within single cells.
本文综述了几种可用于黏液和其他软生物基质流变学研究的非侵入性光散射技术。其中包括用于确定聚合物晶格压缩模量的准弹性光散射技术、可用于测量弱凝胶剪切模量的共振方法、探测黏蛋白聚集体肿胀和收缩的分析方法,以及用于探测单细胞内凝胶化的基于显微镜的光散射技术。