Wallace D C
Med J Aust. 1978 Nov 4;2(10):466, 493-5.
A five-year personal experience of the use of perhexiline maleate (Pexid) in the treatment of severe angina pectoris is presented. Ninety-four patients, all severely incapacitated by cardiac pain, received perhexiline maleate for an average period of 12.2 months. Perhexiline maleate was used either alone or, more commonly, in conjuction with other antianginal therapy, such as beta-adrenergic receptor blocking agents. The results demonstrate that perhexiline maleate is a very effective agent which appears to be safe for long-term usage. Side effects have been frequent, and occasionally bothersome, but all have been transient and dose-dependent. The possibility that the regimens of treatment may materially improve long-term prognosis is raised.
本文介绍了使用马来酸哌克昔林（沛心达）治疗严重心绞痛的五年个人经验。94例患者均因心脏疼痛而严重丧失活动能力，接受马来酸哌克昔林治疗的平均时间为12.2个月。马来酸哌克昔林可单独使用，或更常见的是与其他抗心绞痛疗法联合使用，如β-肾上腺素能受体阻滞剂。结果表明，马来酸哌克昔林是一种非常有效的药物，长期使用似乎是安全的。副作用频繁出现，偶尔会令人烦恼，但均为短暂性且与剂量相关。治疗方案可能会显著改善长期预后的可能性也被提出。
