Shevelyov Yuri Y
Department of Molecular Genetics of Cell, Institute of Molecular Genetics of National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.
Int J Mol Sci. 2020 Dec 13;21(24):9475. doi: 10.3390/ijms21249475.
For a long time, the nuclear lamina was thought to be the sole scaffold for the attachment of chromosomes to the nuclear envelope (NE) in metazoans. However, accumulating evidence indicates that nuclear pore complexes (NPCs) comprised of nucleoporins (Nups) participate in this process as well. One of the Nups, Elys, initiates NPC reassembly at the end of mitosis. Elys directly binds the decondensing chromatin and interacts with the Nup107-160 subcomplex of NPCs, thus serving as a seeding point for the subsequent recruitment of other NPC subcomplexes and connecting chromatin with the re-forming NE. Recent studies also uncovered the important functions of Elys during interphase where it interacts with chromatin and affects its compactness. Therefore, Elys seems to be one of the key Nups regulating chromatin organization. This review summarizes the current state of our knowledge about the participation of Elys in the post-mitotic NPC reassembly as well as the role that Elys and other Nups play in the maintenance of genome architecture.
长期以来，核纤层被认为是后生动物中染色体附着于核膜（NE）的唯一支架。然而，越来越多的证据表明，由核孔蛋白（Nups）组成的核孔复合体（NPCs）也参与了这一过程。其中一种核孔蛋白Elys在有丝分裂末期启动NPC的重新组装。Elys直接结合解聚的染色质，并与NPC的Nup107 - 160亚复合体相互作用，从而作为后续招募其他NPC亚复合体的起始点，并将染色质与重新形成的核膜连接起来。最近的研究还揭示了Elys在间期的重要功能，它在间期与染色质相互作用并影响其紧密程度。因此，Elys似乎是调节染色质组织的关键核孔蛋白之一。本综述总结了我们目前对Elys参与有丝分裂后NPC重新组装的了解情况，以及Elys和其他核孔蛋白在维持基因组结构中所起的作用。
