Departments of Pediatric Surgery.
Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
J Pediatr Hematol Oncol. 2021 Nov 1;43(8):e1186-e1190. doi: 10.1097/MPH.0000000000002042.
This is the first report of an immature sacrococcygeal teratoma with inguinal lymph node metastasis, providing the histologic transformation of an immature teratoma in association with chemotherapy. Incomplete tumor resection with coccygectomy was performed, and the histopathologic diagnosis was a grade 3 immature teratoma. Following the initial surgery, the residual tumors enlarged and the tumors metastasized to the inguinal lymph node, demonstrating immature teratoma without yolk sac tumor components. Although the tumor markers normalized after chemotherapy, the residual tumors had enlarged significantly. Therefore, a complete resection of the residual tumors was performed, and they were found to be mature teratomas.
这是首例报道的伴有腹股沟淋巴结转移的未成熟骶尾部畸胎瘤，提供了化疗相关未成熟畸胎瘤组织学转化的证据。行不完全肿瘤切除术加尾骨切除术，组织病理学诊断为 3 级未成熟畸胎瘤。初始手术后，残余肿瘤增大，肿瘤转移至腹股沟淋巴结，表现为无卵黄囊瘤成分的未成熟畸胎瘤。尽管化疗后肿瘤标志物恢复正常，但残余肿瘤明显增大。因此，行残余肿瘤完全切除术，发现为成熟畸胎瘤。
