Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou.
National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases.
J Hypertens. 2021 Jun 1;39(6):1195-1202. doi: 10.1097/HJH.0000000000002751.
The aim of this study was to investigate the association between neck-to-height ratio (NHR) and arterial stiffness in adults from a community-based Chinese cohort in a cross-sectional study.
We conducted cross-sectional analysis using data from the Kailuan study, a population-based cohort research. Altogether, 18 972 individuals were included in the analysis. Brachial ankle pulse wave velocity (baPWV), anthropometric indexes and cardiovascular risk factors were recorded. Data were analyzed by multiple lineal regression model.
NHR was positively associated with baPWV after adjusted for age, sex, blood pressure, heart rate, BMI, waist-hip ratio, current smoking, fasting blood glucose, serum cholesterol, uric acid, high-sensitivity C reactive protein and creatinine clearance (β = 5.76, P < 0.001), while the association of neck circumference and baPWV was NS after adjusting the variables mentioned above. In subgroups analysis, the association between NHR and baPWV did not reach statistical significance in female, while in males, the association was significant. Interaction effects were observed among BMI stratifications and the individuals with metabolic syndrome and history of cardiovascular events (P for intereaction = 0.002, 0.038 and 0.003, respectively).
The current study demonstrated for the first time that NHR was positively associated with baPWV in community-based population, NHR might be a promising independent predictor for cardiovascular disease.
本研究旨在通过横断面研究调查颈高比（NHR）与成年人动脉僵硬之间的关联。
我们使用来自基于人群的 Kailuan 研究的数据进行了横断面分析。共纳入了 18972 名参与者。记录了肱踝脉搏波速度（baPWV）、人体测量学指标和心血管危险因素。采用多元线性回归模型进行数据分析。
在调整年龄、性别、血压、心率、BMI、腰臀比、当前吸烟、空腹血糖、血清胆固醇、尿酸、高敏 C 反应蛋白和肌酐清除率后，NHR 与 baPWV 呈正相关（β=5.76，P<0.001），而颈围与 baPWV 的相关性在调整上述变量后无统计学意义。在亚组分析中，NHR 与 baPWV 之间的关联在女性中无统计学意义，而在男性中则具有统计学意义。在 BMI 分层和代谢综合征以及心血管事件史的个体中观察到交互作用（P 交互=0.002、0.038 和 0.003）。
本研究首次表明，NHR 与基于人群的人群中的 baPWV 呈正相关，NHR 可能是心血管疾病的一个有前途的独立预测因子。
