School of Chemistry, University of St. Andrews, Purdie Building, St. Andrews KY16 9ST, U.K.
ICGM, Université de Montpellier, CNRS, ENSCM, Montpellier 75005, France.
ACS Appl Mater Interfaces. 2020 Dec 30;12(52):58263-58276. doi: 10.1021/acsami.0c17937. Epub 2020 Dec 16.
A multifaceted study involving focused ion beam scanning electron microscopy techniques, mechanical analysis, water adsorption measurements, and molecular simulations is employed to rationalize the nitric oxide release performance of polyurethane films containing 5, 10, 20, and 40 wt % of the metal-organic framework (MOF) CPO-27-Ni. The polymer and the MOF are first demonstrated to exhibit excellent compatibility. This is reflected in the even distribution and encapsulation of large wt % MOF loadings throughout the full thickness of the films and by the rather minimal influence of the MOF on the mechanical properties of the polymer at low wt %. The NO release efficiency of the MOF is attenuated by the polymer and found to depend on wt % of MOF loading. The formation of a fully connected network of MOF agglomerates within the films at higher wt % is proposed to contribute to a more complex guest transport in these formulations, resulting in a reduction of NO release efficiency and film ductility. An optimum MOF loading of 10 wt % is identified for maximizing NO release without adversely impacting the polymer properties. Bactericidal efficacy of released NO from the films is demonstrated against , with a >8 log reduction in cell density observed after a contact period of 24 h.
采用聚焦离子束扫描电子显微镜技术、力学分析、水吸附测量和分子模拟等多方面手段，研究了含有 5wt%、10wt%、20wt%和 40wt%金属有机骨架（MOF）CPO-27-Ni 的聚氨酯薄膜的一氧化氮释放性能。结果表明，聚合物和 MOF 首先表现出优异的相容性。这体现在高重量百分比 MOF 负载物在薄膜整个厚度范围内的均匀分布和封装，以及 MOF 在低重量百分比下对聚合物力学性能的影响相当小。MOF 的 NO 释放效率被聚合物削弱，并发现其依赖于 MOF 的负载量。在较高的 MOF 负载量下，MOF 团聚体在薄膜内形成完全连接的网络，这可能导致这些配方中客体传输更加复杂，从而降低 NO 释放效率和薄膜的延展性。确定了 10wt%的最佳 MOF 负载量，以在不影响聚合物性能的情况下最大限度地提高 NO 释放效率。从薄膜中释放的 NO 的杀菌效果得到了证明，在接触 24 小时后，观察到细胞密度降低了>8 个对数。
