α2（r）干扰素治疗毛细胞白血病：25例进展报告

The alpha 2 (r) interferon in the treatment of hairy cell leukemia: progressive report of 25 cases.

作者信息

Mandelli F, Cafolla A, Annino L, Amadori S, Gentile A, Bianco P, Dianzani F

机构信息

Department of Human Biopathology, University La Sapienza Rome, Italy.

出版信息

J Biol Regul Homeost Agents. 1987 Oct-Dec;1(4):177-82.

PMID:3332545

Abstract

Twenty-five patients with Hairy Cell Leukemia (HCL), eleven in post-splenectomy progressive disease, have been treated as out-patients with alpha 2 (r) Interferon (IFN) for twelve months. Eighteen patients completed the treatment: four achieved Complete Response (CR), twelve Partial Response (PR) and two Minor Response (MR). The response to IFN has been CR or PR in 89% of cases and MR in 11%. Even if the IFN effective dose and the length of treatment remain to be determined, IFN at relatively low dose seems to become the first treatment of choice in HCL patients. The remaining seven patients, still under treatment, already achieved PR at least.

摘要

25例毛细胞白血病（HCL）患者，其中11例为脾切除术后疾病进展患者，作为门诊患者接受了α2（r）干扰素（IFN）治疗12个月。18例患者完成了治疗：4例达到完全缓解（CR），12例部分缓解（PR），2例微小缓解（MR）。IFN治疗的缓解率为CR或PR的占89%，MR占11%。即使IFN的有效剂量和治疗时长仍有待确定，但相对低剂量的IFN似乎已成为HCL患者的首选治疗方法。其余7例仍在治疗中的患者至少已达到PR。