Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.
Department of Cardiology, People's Hospital of Wuhan University, Wuhan, Hubei.
Medicine (Baltimore). 2020 Dec 11;99(50):e23510. doi: 10.1097/MD.0000000000023510.
Percutaneous coronary intervention (PCI) has been increasingly applied as an effective revascularization strategy in patients with coronary artery disease (CAD). However, recent studies had indicated a higher incidence of depression on post-PCI patients. Acupuncture therapy is effective for depression. However, the treatment effect of depression on post-PCI patients is still not clear. Therefore, this systematic review and meta-analysis protocol is planned to evaluate the efficacy and safety of acupuncture for depression in post-PCI patients.
Six English databases (PubMed, Web of science, Medline, EMBASE, Springer Cochrane Library and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wan fang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database (CNKI) and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to August 1, 2020. Two reviewers will independently conduct article selection, data collection, and risk of bias evaluation. Any disagreement will be resolved by discussion with the third reviewer. Either the fixed-effects or random-effects model will be used for data synthesis based on the heterogeneity test. The change in the scores on the Hamilton depression scale (HAMD) and the Self-rating depression scale (SDS) will be used as the main outcome measure. All-cause mortality, cardiac mortality, Major Adverse Cardiovascular Events (MACEs), rehospitalisation rate and Quality of Life Scale (SF-36) as the secondary outcome. Treatment Emergent Symptom Scale (TESS), General physical examination (temperature, pulse, respiration, blood pressure), Routine examination of blood, urine and stool, Electrocardiogram, Liver and kidney function examination as the security indexs. RevMan5.3.5 will be used for meta-analysis.
This study will provide high-quality evidence to assess the efficacy and safety of acupuncture for depression in post-PCI patients.
This systematic review will explore whether acupuncture is an effective and safe intervention for depression in post-PCI patients.
经皮冠状动脉介入治疗（PCI）已作为冠心病（CAD）患者有效的血运重建策略而被广泛应用。然而，最近的研究表明 PCI 术后患者的抑郁发生率较高。针刺疗法对抑郁有效。然而，针刺治疗 PCI 术后患者抑郁的疗效尚不清楚。因此，本系统评价和荟萃分析方案旨在评估针刺治疗 PCI 术后患者抑郁的疗效和安全性。
本研究将规范检索 6 个英文数据库（PubMed、Web of science、Medline、EMBASE、Springer Cochrane Library 和 WHO 国际临床试验注册平台）和 4 个中文数据库（万方数据库、中国科学引文数据库、中国知网数据库和中国生物医学文献数据库），检索时间从各数据库建库至 2020 年 8 月 1 日。两名评审员将独立进行文献筛选、数据收集和偏倚风险评估。任何意见分歧将通过与第三名评审员讨论解决。根据异质性检验结果，采用固定效应或随机效应模型进行数据合并。主要结局指标为汉密尔顿抑郁量表（HAMD）和抑郁自评量表（SDS）评分的变化。全因死亡率、心脏死亡率、主要不良心血管事件（MACE）、再住院率和健康状况量表（SF-36）为次要结局。治疗中出现的症状量表（TESS）、一般体格检查（体温、脉搏、呼吸、血压）、常规血、尿、便检查、心电图、肝肾功能检查为安全性指标。RevMan5.3.5 将用于荟萃分析。
本研究将提供高质量的证据，以评估针刺治疗 PCI 术后患者抑郁的疗效和安全性。
本系统评价将探讨针刺是否是 PCI 术后患者抑郁的有效、安全干预措施。
