Zeng Shaoxue, Zhang Ting, Madigan Michele C, Fernando Nilisha, Aggio-Bruce Riemke, Zhou Fanfan, Pierce Matthew, Chen Yingying, Huang Lianlin, Natoli Riccardo, Gillies Mark C, Zhu Ling
Save Sight Institute, The University of Sydney, Sydney, NSW, Australia.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Front Cell Neurosci. 2020 Nov 19;14:577935. doi: 10.3389/fncel.2020.577935. eCollection 2020.
Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by photoreceptors. Enriched in the interphotoreceptor matrix (IPM) and recycled by the retinal pigment epithelium (RPE), IRBP is essential for the vision of all vertebrates as it facilitates the transfer of retinoids in the visual cycle. It also helps to transport lipids between the RPE and photoreceptors. The thiol-dependent antioxidant activity of IRBP maintains the delicate redox balance in the normal retina. Thus, its dysfunction is suspected to play a role in many retinal diseases. We have reviewed here the latest research on IRBP in both retinal health and disease, including the function and regulation of IRBP under retinal stress in both animal models and the human retina. We have also explored the therapeutic potential of targeting IRBP in retinal diseases. Although some technical barriers remain, it is possible that manipulating the expression of IRBP in the retina will rescue or prevent photoreceptor degeneration in many retinal diseases.
光感受器间维生素A结合蛋白（IRBP），也称为视黄醇结合蛋白3（RBP3），是一种由光感受器特异性分泌的亲脂性糖蛋白。IRBP在光感受器间基质（IPM）中富集并由视网膜色素上皮（RPE）循环利用，它在所有脊椎动物的视觉中至关重要，因为它促进了视觉循环中类视黄醇的转运。它还有助于在RPE和光感受器之间运输脂质。IRBP的硫醇依赖性抗氧化活性维持正常视网膜中微妙的氧化还原平衡。因此，怀疑其功能障碍在许多视网膜疾病中起作用。我们在此回顾了关于IRBP在视网膜健康和疾病方面的最新研究，包括动物模型和人类视网膜中视网膜应激下IRBP的功能和调节。我们还探讨了靶向IRBP治疗视网膜疾病的潜力。尽管仍然存在一些技术障碍，但在视网膜中操纵IRBP的表达有可能挽救或预防许多视网膜疾病中的光感受器退化。
