Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Departamento de Clínica Médica, Botucatu, SP, Brasil.
IBD Unit, St Mark's Hospital, London, United Kingdom.
Arq Gastroenterol. 2020 Sep-Dec;57(4):491-497. doi: 10.1590/S0004-2803.202000000-86.
This study aims to evaluate patient's preferences in the choice of their therapy and the factors that influence this choice.
This cross-sectional study enrolled 101 outpatients with Crohn's disease or ulcerative colitis. The inclusion criteria were age ≥18 years and no previous exposure to biological therapy. Patients' preferences were assessed through questions that addressed the preferred mode of administration (oral, subcutaneous, or intravenous) and the factors that determined the choice of medication (efficacy, medical indication, fear of medication, convenience, mode of application, and personal doctors' indication).
The mean age was 43.6±13.5 years, 75.3% were female, and 81.2% were cases of ulcerative colitis. Regarding the mode of administration, the majority of patients preferred oral (87.1%), followed by intravenous (6.93%) and subcutaneous (5.94%) medications. The reasons were "I prefer to take it at home" (42.57%), "I have more freedom" (36.63%), "I don't like self-application" (29.70%), and "I believe it works better" (19.80%). Younger patients and patients in clinical disease activity preferred intravenous mode compared to the oral route (P<0.05). Doctor's opinion (98%) was an important factor associated with the medication choice.
Oral route was the preferred mode of administration and most patients took their physician's opinion into account in their choice of medication.
本研究旨在评估患者在治疗选择方面的偏好以及影响这种选择的因素。
这项横断面研究纳入了 101 例克罗恩病或溃疡性结肠炎门诊患者。纳入标准为年龄≥18 岁且以前未接受过生物治疗。通过询问患者首选的给药方式（口服、皮下或静脉）以及决定药物选择的因素（疗效、医学指征、对药物的恐惧、便利性、给药方式和医生的建议）来评估患者的偏好。
患者的平均年龄为 43.6±13.5 岁，75.3%为女性，81.2%为溃疡性结肠炎患者。关于给药方式，大多数患者首选口服（87.1%），其次是静脉（6.93%）和皮下（5.94%）给药。原因是“我更喜欢在家服用”（42.57%）、“我更自由”（36.63%）、“我不喜欢自行给药”（29.70%）和“我相信它效果更好”（19.80%）。与口服途径相比，年轻患者和临床疾病活动患者更倾向于静脉途径（P<0.05）。医生的意见（98%）是与药物选择相关的重要因素。
口服途径是首选的给药方式，大多数患者在选择药物时会考虑医生的意见。
