Karapinar Edanur, YunusoĞlu Ceren, Tekin Betül, Dede Hava Özlem, Bebek Nerses, Baykan Betül, GÜrses Candan
Istanbul University, Istanbul School of Medicine, Department of Neurology, Fatih, İstanbul, Turkey.
University of Health Sciences Prof. Dr. Mazhar Osman Bakırköy Research and Training Hospital for Psychiatry, Neurology, Neurosurgery, Department of Neurology, Bakırköy, Istanbul, Turkey.
Arq Neuropsiquiatr. 2020 Dec;78(12):772-777. doi: 10.1590/0004-282X20200064.
We aimed to identify sleep disorders in patients with epilepsy and compare this group with a healthy population. We also analyzed the features of sleep disorders in patients with epilepsy to demonstrate the effect of seizures and seizure types on sleep.
Our study assessed 43 patients with epilepsy and 53 age- and gender-matched healthy controls. The demographic and clinical data of all participants were recorded. The Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (PSQI), International Restless Legs Syndrome Study Group Rating Scale, Berlin Questionnaire, and Beck Depression Inventory (BDI) were administered to all study subjects. The interview used to evaluate insomnia is based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition - DSM-5 diagnostic criteria.
Twenty-four patients (55.8%) and 26 controls (49.1%) are women. The mean age of patients and controls was 34.2±11.37 (16-71) and 34.6±11.28 (16-77), respectively. Patients with epilepsy had depression more often than controls, a result that was statistically significant (p<0.0001). We found no statistically significant difference between sleep parameters of patients and controls with normal BDI scores (p>0.05). Patients with depression had worse results on the Berlin Questionnaire and PSQI total score, with statistical significance (p=0.002). Nocturnal seizures, seizure type, and drug treatment had no effect on sleep (p>0.05).
We concluded that depression rather than epilepsy negatively affects sleep, suggesting that all patients should be asked about their mood and sleep complaints.
我们旨在识别癫痫患者的睡眠障碍，并将该组患者与健康人群进行比较。我们还分析了癫痫患者睡眠障碍的特征，以证明癫痫发作及发作类型对睡眠的影响。
我们的研究评估了43例癫痫患者和53例年龄及性别匹配的健康对照者。记录了所有参与者的人口统计学和临床数据。对所有研究对象进行了爱泼华嗜睡量表、匹兹堡睡眠质量指数（PSQI）、国际不宁腿综合征研究组评分量表、柏林问卷和贝克抑郁量表（BDI）的测评。用于评估失眠的访谈基于《精神疾病诊断与统计手册》第5版（DSM-5）的诊断标准。
24例患者（55.8%）和26例对照者（49.1%）为女性。患者和对照者的平均年龄分别为34.2±11.37岁（16 - 71岁）和34.6±11.28岁（16 - 77岁）。癫痫患者患抑郁症的频率高于对照者，这一结果具有统计学意义（p<0.0001）。我们发现BDI评分正常的患者和对照者的睡眠参数之间无统计学显著差异（p>0.05）。抑郁症患者在柏林问卷和PSQI总分上的结果更差，具有统计学意义（p = 0.002）。夜间发作、发作类型和药物治疗对睡眠无影响（p>0.05）。
我们得出结论，是抑郁症而非癫痫对睡眠产生负面影响，这表明应询问所有患者的情绪和睡眠问题。
