Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Mol Pharm. 2021 Jan 4;18(1):18-32. doi: 10.1021/acs.molpharmaceut.0c01089. Epub 2020 Dec 17.
Poly(lactic--glycolic acid) (PLGA) has been used for long-acting injectable drug delivery systems for more than 30 years. The factors affecting the properties of PLGA formulations are still not clearly understood. The drug release kinetics of PLGA microparticles are influenced by many parameters associated with the formulation composition, manufacturing process, and post-treatments. Since the drug release kinetics have not been explainable using the measurable properties, formulating PLGA microparticles with desired drug release kinetics has been extremely difficult. Of the various properties, the glass transition temperature, , of PLGA formulations is able to explain various aspects of drug release kinetics. This allows examination of parameters that affect the of PLGA formulations, and thus, affecting the drug release kinetics. The impacts of the terminal sterilization on the and drug release kinetics were also examined. The analysis of drug release kinetics in relation to the of PLGA formulations provides a basis for further understanding of the factors controlling drug release.
聚（乳酸-乙醇酸）（PLGA）已被用于长效注射药物传递系统超过 30 年。影响 PLGA 制剂性能的因素仍未被清楚地理解。PLGA 微球的药物释放动力学受许多与制剂组成、制造工艺和后处理相关的参数影响。由于药物释放动力学无法用可测量的性质来解释，因此用期望的药物释放动力学来配制 PLGA 微球极其困难。在各种性质中，PLGA 制剂的玻璃化转变温度 ，能够解释药物释放动力学的各个方面。这允许检查影响 PLGA 制剂 的 参数，从而影响药物释放动力学。还研究了终端灭菌对 和药物释放动力学的影响。分析药物释放动力学与 PLGA 制剂 的关系为进一步理解控制药物释放的因素提供了基础。
