Mayo Clinic Foundation, Rochester, MN, USA.
Gunderson Medical Foundation, La Crosse, WI, USA.
Int J Dermatol. 2021 Feb;60(2):185-189. doi: 10.1111/ijd.15370. Epub 2020 Dec 17.
The purpose of this study was to retrospectively assess clinical characteristics and mortality rate of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients who developed disseminated intravascular coagulation (DIC).
A systematic retrospective chart review of all patients with concurrent clinical diagnosis of DIC and SJS/TEN between July 1, 2012, and January 1, 2020, at the Mayo Clinic was performed.
The incidence of DIC in patients with SJS/TEN was 1.3% at our institution (5 of 396 DIC patients). Triggers of SJS/TEN included lamotrigine, clofarabine, antibiotics, and sepsis. Two patients diagnosed with SJS and two patients with TEN succumbed to the disease.
DIC is a rare underlying risk in patients with SJS/TEN and is associated with increased mortality. Early clinician awareness and aggressive intervention is advised.
本研究旨在回顾性评估发生弥漫性血管内凝血（DIC）的史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）患者的临床特征和死亡率。
对 2012 年 7 月 1 日至 2020 年 1 月 1 日期间在 Mayo 诊所同时临床诊断为 DIC 和 SJS/TEN 的所有患者进行系统的回顾性图表审查。
本机构 SJS/TEN 患者中 DIC 的发生率为 1.3%（396 例 DIC 患者中有 5 例）。SJS/TEN 的诱因包括拉莫三嗪、克拉屈滨、抗生素和脓毒症。两名患者被诊断为 SJS，两名患者被诊断为 TEN，均死于该病。
DIC 是 SJS/TEN 患者中罕见的潜在风险因素，与死亡率增加相关。建议临床医生早期注意并积极干预。
