自身免疫性疾病中自身抗体的最新进展。

An updated advance of autoantibodies in autoimmune diseases.

机构信息

Institute of Clinical Immunology, The Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou 510630, China.

Ohio University Heritage College of Osteopathic Medicine, Dublin, OH 43016, United States.

出版信息

Autoimmun Rev. 2021 Feb;20(2):102743. doi: 10.1016/j.autrev.2020.102743. Epub 2020 Dec 14.

DOI:10.1016/j.autrev.2020.102743

PMID:33333232

Abstract

Autoantibodies are abnormal antibodies which are generated by pathogenic B cells when targeting an individual's own tissue. Autoantibodies have been identified as a symbol of autoimmune disorders and are frequently considered a clinical marker of these disorders. Autoimmune diseases, including system lupus erythematosus and rheumatoid arthritis, consist of a series of disorders that share some similarities and differences. They are characterized by chronic, systemic, excessive immune activation and inflammation and involve in almost all body tissues. Autoimmune diseases occur more frequently in women than men due to hormonal impacts. In this review we systemically introduce and summarize the latest advances of various autoantibodies in multiple autoimmune diseases.

摘要

自身抗体是致病性 B 细胞针对个体自身组织时产生的异常抗体。自身抗体已被确定为自身免疫性疾病的标志，并且经常被认为是这些疾病的临床标志物。包括系统性红斑狼疮和类风湿关节炎在内的自身免疫性疾病由一系列具有某些相似和不同之处的疾病组成。它们的特征是慢性、系统性、过度的免疫激活和炎症，几乎涉及所有身体组织。由于激素的影响，女性比男性更容易患自身免疫性疾病。在这篇综述中，我们系统地介绍和总结了多种自身免疫性疾病中各种自身抗体的最新进展。