Cerni C M, Rella W A, Bicker U
Osterr Z Onkol. 1977;4(1):20-2.
The new cancerostatic substance 4-imino-1,3-diazabicycle- (3.1.0.)-hexan-2-on was investigated in DBF1 mice in respect to its effects on antibody producing B-lymphocytes and T-lymphocytes. It was shown that BM 06.002 has no definitive influence on immunocompetence when used at a low concentration (1 mg/kg). At higher concentrations of 5 up to 20 mg/kg a stimulation of T-lymphocytes was found which was constant at a concentration of 20 mg/kg for more than three weeks after the single injection of 20 mg/kg. Using the haemolytic plaque test, a stimulation of the antibody producing B-cells was observed on day 3 and 12 after treatment. On day 5 a transitory suppression of the lymphocyte functions was observed in both test systems.
对新型抗癌物质4-亚氨基-1,3-二氮杂双环-(3.1.0.)-己烷-2-酮在DBF1小鼠中进行了研究，观察其对产生抗体的B淋巴细胞和T淋巴细胞的影响。结果表明，低浓度（1毫克/千克）使用时，BM 06.002对免疫能力没有决定性影响。在5至20毫克/千克的较高浓度下，发现对T淋巴细胞有刺激作用，单次注射20毫克/千克后，在20毫克/千克的浓度下这种刺激持续超过三周。使用溶血空斑试验，在治疗后第3天和第12天观察到对产生抗体的B细胞有刺激作用。在第5天，在两个测试系统中均观察到淋巴细胞功能的短暂抑制。
