Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism, University College of Medical Sciences (University of Delhi) & GTB Hospital, Delhi, India.
Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism, University College of Medical Sciences (University of Delhi) & GTB Hospital, Delhi, India.
J Clin Lipidol. 2021 Jan-Feb;15(1):227-234. doi: 10.1016/j.jacl.2020.11.002. Epub 2020 Nov 7.
Individuals with family history of diabetes carry nearly double the risk of diabetes than those without. However, the mechanism for this increased risk of diabetes in them is not fully understood.
To study fasting and postprandial triglyceride levels in individuals with normal glucose tolerance (NGT) who had family history of diabetes and to ascertain their association with insulin resistance.
Fasting triglyceride levels and HOMA-IR were compared in 671 NGT individuals with and without a family history of diabetes. A standardized fat challenge test was also done in one tenth of individuals of each group and postprandial triglyceride responses were compared between them. Association of HOMA-IR with fasting and postprandial triglyceride levels was ascertained through pearson's coefficient of correlation.
Individuals with family history of diabetes had significantly higher HOMA-IR (P < 0.001) and significantly higher postprandial triglyceride AUC (P = 0.04) after standardized fat meal despite having similar fasting triglyceride levels (P = 0.51) as those without family history of diabetes. Fasting as well as postprandial triglyceride levels significantly correlated with HOMA-IR (r = 0.35, P < 0.001 and r = 0.39, P = 0.04) only in those with a positive family history of diabetes but not in those without. Triglyceride levels mediated the associations of BMI (Δ β = -0.053) and waist circumference (Δ β = -0.075) with HOMA-IR.
Triglyceride levels, both in the fasting and the postprandial state are associated with insulin resistance in NGT individuals with a family history of diabetes but not in those without.
有糖尿病家族史的个体患糖尿病的风险几乎是无家族史个体的两倍。然而，这种糖尿病风险增加的机制尚未完全阐明。
研究糖耐量正常（NGT）个体中，有和无糖尿病家族史者的空腹和餐后甘油三酯水平，并确定其与胰岛素抵抗的关系。
比较 671 名有和无糖尿病家族史的 NGT 个体的空腹甘油三酯水平和 HOMA-IR。还对每组十分之一的个体进行标准化脂肪负荷试验，并比较其餐后甘油三酯反应。通过 Pearson 相关系数确定 HOMA-IR 与空腹和餐后甘油三酯水平的相关性。
尽管空腹甘油三酯水平与无家族史者相似（P = 0.51），但有家族史者的 HOMA-IR（P < 0.001）和标准化脂肪餐后餐后甘油三酯 AUC（P = 0.04）明显更高。空腹和餐后甘油三酯水平与 HOMA-IR 显著相关（r = 0.35，P < 0.001 和 r = 0.39，P = 0.04），仅在有阳性家族史者中，而在无家族史者中则不相关。甘油三酯水平介导 BMI（Δβ = -0.053）和腰围（Δβ = -0.075）与 HOMA-IR 的相关性。
在有糖尿病家族史的 NGT 个体中，空腹和餐后甘油三酯水平与胰岛素抵抗相关，但在无家族史者中则不相关。
