School of Statistics, ShanXi University of Finance and Economics, Taiyuan, Shanxi Province.
Department of Cardiovascular Medicine, ShanXi Bethune Hospital, Taiyuan, Shanxi Province, China.
Ann Clin Lab Sci. 2020 Nov;50(6):775-780.
To investigate the relationship between Transient Receptor Potential Vanilloid 6 (TRPV6) and ST-elevation acute myocardial infarction (STEMI) patients.
This observational research included a total of 221 patients with STEMI admitted during January 2017~August 2019. Additionally, 50 cases of non-ST-elevation acute myocardial infarction (NSTEMI) patients and 50 healthy individuals were enrolled as the control. Serum levels of TRPV6 were detected by ELISA method. The relationship between TRPV6, clinical characteristics, laboratory indices of CK-MB, TnI, NT-pro-B-type natriuretic peptide (NT-pro-BNP), C-reactive protein (CRP), and the left ventricular ejection fraction (LVEF%) was analyzed by statistical methods. K-M curve was performed for survival time.
Serum levels of TRPV6 were remarkably lower in STEMI and NSTEMI patients compared with the healthy control. Levels of NT-pro-BNP and CK-MB were significantly higher and serum levels of TRPV6 were dramatically lower in deceased STEMI patients in comparison with the surviving patients. The levels of TRPV6 were negatively correlated with CK-MB and NT-pro-BNP. Meanwhile, TRPV6 was negatively expressed in tissues of STEMI patients and positively expressed in normal tissues. Patients with lower TRPV6 levels had remarkably lower LVEF ratio, higher GRACE scores, higher CK-MB and NT-pro-BNP levels, as well as higher ratios of cardiovascular death, malignant arrhythmia, cumulative MACE, and shorter survival time than patients with higher TRPV6.
The lower expression of TRPV6 was associated with poor clinical outcomes and prognosis of STEMI patients.
探讨瞬时受体电位香草酸 6（TRPV6）与 ST 段抬高型急性心肌梗死（STEMI）患者的关系。
本观察性研究共纳入 2017 年 1 月至 2019 年 8 月期间收治的 221 例 STEMI 患者，另选取同期收治的 50 例非 ST 段抬高型急性心肌梗死（NSTEMI）患者和 50 例健康对照者。采用 ELISA 法检测 TRPV6 血清水平，分析 TRPV6 与 CK-MB、TnI、NT-pro-B 型利钠肽（NT-pro-BNP）、C 反应蛋白（CRP）等实验室指标及左心室射血分数（LVEF%）与临床特征的关系，采用 K-M 曲线进行生存时间分析。
STEMI 和 NSTEMI 患者血清 TRPV6 水平明显低于健康对照组，死亡 STEMI 患者的 NT-pro-BNP 和 CK-MB 水平显著高于存活患者，而血清 TRPV6 水平显著低于存活患者。TRPV6 水平与 CK-MB 和 NT-pro-BNP 呈负相关。同时，TRPV6 在 STEMI 患者组织中呈低表达，在正常组织中呈高表达。TRPV6 水平较低的患者的 LVEF 比值显著较低，GRACE 评分、CK-MB 和 NT-pro-BNP 水平较高，心血管死亡、恶性心律失常、累积 MACE 和生存时间较短的比例较高。
TRPV6 低表达与 STEMI 患者的临床转归和预后不良相关。
