Kobayashi Kazuki, Einama Takahiro, Fujinuma Ibuki, Tsunenari Takazumi, Miyata Yoichi, Iwasaki Toshimitsu, Asakuma Junichi, Soga Shigeyoshi, Shinmoto Hiroshi, Tsujimoto Hironori, Hase Kazuo, Ueno Hideki, Kishi Yoji
Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
Mol Clin Oncol. 2021 Feb;14(2):22. doi: 10.3892/mco.2020.2184. Epub 2020 Dec 3.
Sarcoidosis is a multisystemic granulomatous disease. It is rarely isolated in the spleen. The present report describes a case of isolated splenic sarcoidosis that was diagnosed histologically following laparoscopic splenectomy. A 76-year-old woman, who underwent radical nephroureterectomy 7 years earlier for left renal pelvic cancer and mastectomy 6 years earlier for left breast cancer in another facility, was referred to our hospital for assessment of splenic tumors that were identified during a follow-up examination. The computed tomography scans revealed multiple nodules in the spleen, which had increased in size over 2 years. Positron emission tomography revealed accumulation of [18F]-fluorodeoxyglucose in the spleen. Laparoscopic splenectomy was performed and the diagnosis of sarcoidosis was confirmed histologically. A review of previous reports and the present case suggested that diagnosis of splenic sarcoidosis should be considered when the CT scans show multinodular splenic tumors, and sarcoidosis might be associated with malignant tumors.
结节病是一种多系统肉芽肿性疾病。脾脏孤立性受累极为罕见。本报告描述了一例孤立性脾结节病病例，该病例经腹腔镜脾切除术后经组织学确诊。一名76岁女性，7年前因左肾盂癌在外院接受根治性肾输尿管切除术，6年前因左乳腺癌在外院接受乳房切除术，此次因在随访检查中发现脾脏肿瘤而转诊至我院进行评估。计算机断层扫描显示脾脏有多个结节，这些结节在2年多的时间里增大。正电子发射断层扫描显示脾脏有[18F] - 氟脱氧葡萄糖摄取。实施了腹腔镜脾切除术，组织学检查确诊为结节病。回顾既往报道及本病例提示，当CT扫描显示脾脏有多发性结节性肿瘤时，应考虑脾结节病的诊断，且结节病可能与恶性肿瘤有关。
