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KLK7在卵巢癌中的表达及预后分析

Analysis of expression and prognosis of KLK7 in ovarian cancer.

作者信息

Chen Erhua, Zhu Huifang, Yang Yue, Wang Ling, Zhang Jianhua, Han Yonghong, Liu Xiang

机构信息

Department of Pharmacy and Medicine Pharmacy, Jiang Su College of nursing, Huaian, 223005, China.

出版信息

Open Med (Wars). 2020 Sep 30;15(1):932-939. doi: 10.1515/med-2020-0139. eCollection 2020.

DOI:10.1515/med-2020-0139
PMID:33336051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7712299/
Abstract

BACKGROUND

Ovarian cancer is one of the common malignant tumors in female reproductive organs. Kallikrein-related peptidase (KLK) 7 is a secreted serine peptidase that is related to different cancer. To investigate the expression and significance of KLK7 in ovarian cancer.

MATERIALS AND METHODS

The expression of KLK7 in human ovarian cancer was evaluated by Oncomine and Cancer Cell Line Encyclopedia database. Then the co-expression genes relevant to the gene were analyzed by the Pearson correlation test. Finally, the impact of KLK7 on clinical prognosis was investigated in distinct subtypes of ovarian cancer patients by UALCAN database and Kaplan-Meier plotter database.

RESULTS

It was found that the expression of KLK7 was higher in ovarian cancer compared with other types of cancer, such as gastric cancer and pancreatic cancer. The expression of KLK7 was found to be increased in four various ovarian cancer data sets compared with the healthy tissues. In addition, upregulation of KLK7 expression was associated with age and cancer stage. Moreover, survival analysis revealed that higher KLK7 expression was negatively associated with progression-free survival.

CONCLUSION

Knowledge of the expression of KLK7 may be useful for better understanding the outcome in ovarian cancer patients.

摘要

背景

卵巢癌是女性生殖器官常见的恶性肿瘤之一。激肽释放酶相关肽酶（KLK）7是一种与不同癌症相关的分泌型丝氨酸肽酶。旨在研究KLK7在卵巢癌中的表达及意义。

材料与方法

通过Oncomine和癌症细胞系百科全书数据库评估KLK7在人卵巢癌中的表达。然后通过Pearson相关检验分析与该基因相关的共表达基因。最后，通过UALCAN数据库和Kaplan-Meier绘图仪数据库研究KLK7对不同亚型卵巢癌患者临床预后的影响。

结果

发现与胃癌和胰腺癌等其他类型癌症相比，KLK7在卵巢癌中的表达更高。与健康组织相比，在四个不同的卵巢癌数据集中发现KLK7的表达增加。此外，KLK7表达上调与年龄和癌症分期相关。而且，生存分析显示较高的KLK7表达与无进展生存期呈负相关。

结论

了解KLK7的表达可能有助于更好地了解卵巢癌患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/dc20179c9a44/j_med-2020-0139-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/3e7575aebf95/j_med-2020-0139-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/40772251feec/j_med-2020-0139-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/1f882246e218/j_med-2020-0139-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/7786145c28f7/j_med-2020-0139-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/284f67faba32/j_med-2020-0139-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/cce799d3b230/j_med-2020-0139-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/dc20179c9a44/j_med-2020-0139-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/3e7575aebf95/j_med-2020-0139-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/40772251feec/j_med-2020-0139-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/1f882246e218/j_med-2020-0139-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/7786145c28f7/j_med-2020-0139-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/284f67faba32/j_med-2020-0139-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/cce799d3b230/j_med-2020-0139-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5155/7712299/dc20179c9a44/j_med-2020-0139-fig007.jpg

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J Ovarian Res. 2019 May 25;12(1):49. doi: 10.1186/s13048-019-0523-3.
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5
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