一名患有原发性皮肤边缘区淋巴瘤的青少年出现 Darier 征。

Darier sign in a teenager with primary cutaneous marginal zone lymphoma.

作者信息

Leonard Nicholas, Lal Karan, Luffman Christina, O'Donnell Patrick, Jolley Lindsey, Belazarian Leah

机构信息

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.

出版信息

Pediatr Dermatol. 2021 Mar;38(2):494-496. doi: 10.1111/pde.14488. Epub 2020 Dec 18.

DOI:10.1111/pde.14488

PMID:33336458

Abstract

Primary cutaneous marginal zone lymphoma (PCMZL) is a low-grade B-cell lymphoma that arises in the skin. An adolescent male presented with dermal nodules on the arms, legs, and back with a positive Darier sign, ultimately diagnosed as PCMZL. The nodules demonstrated a partial response to doxycycline in the setting of prior Lyme disease followed by a complete response to rituximab.

摘要

原发性皮肤边缘区淋巴瘤（PCMZL）是一种起源于皮肤的低度B细胞淋巴瘤。一名青少年男性双臂、双腿及背部出现皮肤结节，Darier征阳性，最终被诊断为PCMZL。这些结节在既往莱姆病的情况下对强力霉素有部分反应，随后对利妥昔单抗有完全反应。