Johnson A L, Stein L E, Roe S C
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61801.
Vet Surg. 1987 Mar-Apr;16(2):146-50. doi: 10.1111/j.1532-950x.1987.tb00927.x.
A commercially available collagen sponge acting as a cylindrical retainer containing autogenous cancellous bone graft was proposed for treatment of full thickness cortical defects in dogs. Three groups of three dogs each were subjected to removal of at least 1.5 cm of the tibial diaphyses. All tibias were stabilized with bilateral external fixators. Group 1 received collagen surrounding an autogenous cancellous bone graft. Group 2 received collagen and group 3 received no treatment of the ostectomy site. The collagen sponge appeared to allow vascularization of the bone graft as evidenced by new bone formation and was resorbed by 3 months after implantation. Radiographic, histomorphologic, and histomorphometric evaluation at 3 months after surgery showed a greater per cent of bone in the ostectomy site in group 1.
一种市售的胶原蛋白海绵被用作圆柱形固定器，其中包含自体松质骨移植材料，用于治疗犬的全层皮质缺损。将三组，每组三只犬的胫骨干至少1.5厘米的骨段切除。所有胫骨均用双侧外固定器固定。第1组接受围绕自体松质骨移植材料的胶原蛋白。第2组接受胶原蛋白，第3组对骨切除部位不进行处理。胶原蛋白海绵似乎能使骨移植材料血管化，新骨形成证明了这一点，并且在植入后3个月被吸收。术后3个月的影像学、组织形态学和组织形态计量学评估显示，第1组骨切除部位的骨百分比更高。
