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单侧甲状腺全叶切除术对单个甲状腺恶性结节来说是足够的治疗方式吗?67例年龄在5至18岁之间接受手术的患者(作者译)

[Is unilateral total lobectomy adequate treatment for a single malignant thyroid nodule? 67 patients operated upon between 5 and 18 years age (author's transl)].

作者信息

Blondeau P, Legros A, René L

出版信息

Nouv Presse Med. 1977 Sep 10;6(29):2583-7.

PMID:333385
Abstract

In the treatment of thyroid carcinoma, there is still some discussion about the best operation for a solitary and well encapsulated nodule. 18 years ago, it was decided to treat every case of "cold" thyroid nodule by total lobectomy and isthmectomy. 56 patients were reevaluated 5 to 18 years after such limited operation for malignant nodules. 8 of them died between the 19 th month and the 14 th year after surgery, the death being possibly related to the thyroid cancer in only 4 patients, but without any clinical evidence of local recurrence. Among 50 surviving patients, only one controlateral recurrence was observed, two years after lobectomy; it was treated by surgical totalisation of thyroidectomy, without any new recurrence after 10 more years. These results (although the small number of cases, and too short follow-up exclude definitive conclusions) are comparable to those obtained by a more aggresive surgical approach, but have the great advantage of total absence of any functional sequellae. So are we encouraged to go further in the experience of a rather conservative surgery in the treatment of uninodular thyroid carcinoma.

摘要

在甲状腺癌的治疗中,对于孤立性且包膜完整的结节,最佳手术方式仍存在一些争议。18年前,决定对每例“冷”甲状腺结节行甲状腺全叶切除术及峡部切除术。对56例因恶性结节接受这种有限手术的患者在术后5至18年进行了重新评估。其中8例在术后第19个月至第14年死亡,仅4例死亡可能与甲状腺癌有关,但无任何局部复发的临床证据。在50例存活患者中,仅1例在甲状腺叶切除术后两年出现对侧复发;通过甲状腺全切术进行治疗,此后10多年未出现新的复发。这些结果(尽管病例数少且随访时间短,无法得出明确结论)与采用更积极手术方式获得的结果相当,但具有完全没有任何功能后遗症的巨大优势。因此,我们被鼓励在单发性甲状腺癌的治疗中进一步积累较为保守手术的经验。

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