Ushakov V L, Malashenkova I K, Kostyuk G P, Zakharova N V, Krynskiy S A, Kartashov S I, Ogurtsov D P, Bravve L V, Kaydan M A, Hailov N A, Chekulaeva E I, Didkovsky N A
National Researh Center «Kurchatov Institute», Moscow, Russia.
Alekseev Mental-health Hospital No1, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(11):70-78. doi: 10.17116/jnevro202012011170.
To search for the relationship between the results of functional imaging, immunological parameters and laboratory markers of inflammation in schizophrenia, taking into account cognitive impairment in patients, and to consider the possibility of using a multidisciplinary approach to diagnosis, treatment and prognosis of schizophrenia.
The study included 25 patients with schizophrenia and 13 healthy volunteers. Psychiatric scales were administered to evaluate the patient's condition. The main indicators of humoral immunity, the level of markers of inflammation, key pro-inflammatory and anti-inflammatory cytokines, and growth factor VEGF were determined by ELISA. Brain MRI was performed. All calculated tractographic data are included in the connection database to study the effect of immunological markers and the degree of severity of cognitive impairment.
Levels of markers of systemic inflammation and growth factor VEGF-A as well as the activation of humoral immunity are increased in patients with schizophrenia compared with controls. For the first time, the relationship of immunological parameters with the coefficient of quantitative anisotropy in the area of the corpus callosum in schizophrenia was revealed. The results indicate the possible value of indicators of the activation of the humoral immune response and systemic inflammation as markers of neurophysiological changes and cognitive dysfunction in schizophrenia.
考虑到精神分裂症患者的认知障碍，探寻功能成像结果、免疫参数与炎症实验室指标之间的关系，并探讨采用多学科方法对精神分裂症进行诊断、治疗和预后评估的可能性。
该研究纳入了25例精神分裂症患者和13名健康志愿者。采用精神科量表评估患者病情。通过酶联免疫吸附测定法（ELISA）测定体液免疫的主要指标、炎症标志物水平、关键促炎和抗炎细胞因子以及生长因子VEGF。进行脑部磁共振成像（MRI）检查。所有计算得出的纤维束成像数据都纳入连接数据库，以研究免疫标志物的作用以及认知障碍的严重程度。
与对照组相比，精神分裂症患者的全身炎症标志物和生长因子VEGF - A水平以及体液免疫激活程度均有所升高。首次揭示了精神分裂症患者免疫参数与胼胝体区域定量各向异性系数之间的关系。结果表明，体液免疫反应激活和全身炎症指标可能作为精神分裂症神经生理变化和认知功能障碍的标志物具有一定价值。
