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退行性腰椎狭窄症手术:临床疗效的预测因素——1001 例患者的经验。

Degenerative Lumbar Stenosis Surgery: Predictive Factors of Clinical Outcome-Experience with 1001 Patients.

机构信息

Department of Neurosurgery, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Department of Vertebral Surgery, Casa di Cura Città di Pavia, Pavia, Italy.

Department of Neurosurgery, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Università degli Studi di Milano, Scuola di Specializzazione in Neurochirurgia, Milan, Italy.

出版信息

World Neurosurg. 2021 Mar;147:e306-e314. doi: 10.1016/j.wneu.2020.12.048. Epub 2020 Dec 16.

Abstract

BACKGROUND

Degenerative lumbar spinal stenosis (DLSS) carries a high risk of morbidity and represents a financial burden to society. A late diagnosis can lead to severe disability. Although lumbar decompressive surgery has been widely used worldwide, the proper preoperative factors to define the ideal candidates for decompression are missing.

METHODS

A total of 1001 patients who had undergone decompressive surgery from 2012 to 2019 for DLSS were screened for the presence of 9 clinical and radiological parameters. For all cases, the differences between the baseline and postoperative Oswestry disability index were calculated and the results categorized as 5 different classes (ranging from very poor outcomes to excellent outcomes) according to the specific scores. Generalized ordinal logistic regression was then used to analyze the significance of the 9 parameters (coded as dummy variables) in predicting the outcome as measured by Oswestry disability index improvement after surgery.

RESULTS

Of the 9 parameters, 8 were found to be significant predictors. The radiological grade of compression was the strongest, followed by polyneuropathy, obesity, symptom duration, gait autonomy, radicular deficits, American Society of Anesthesiologists score, and level of surgery. In contrast, previous back surgery was not predictive of the outcome.

CONCLUSIONS

Our findings have indicated that the ideal candidate for surgery will have the following preoperative characteristics: Schizas grade D, no signs of peripheral polyneuropathy, body mass index <30 kg/m, symptom duration of <2 years, gait autonomy <100 m, no radicular deficits, 1 level of stenosis, and an American Society of Anesthesiologists score of 1, 2, or 3.

摘要

背景

退行性腰椎管狭窄症(DLSS)发病率高,给社会带来沉重的经济负担。如果诊断较晚,可能会导致严重的残疾。尽管全球范围内广泛应用了腰椎减压手术,但仍缺乏明确的术前因素来确定减压的理想患者。

方法

对 2012 年至 2019 年间因 DLSS 接受减压手术的 1001 例患者进行了 9 项临床和影像学参数的筛查。对所有病例,计算基线和术后 Oswestry 功能障碍指数之间的差异,并根据特定评分将结果分为 5 个不同类别(从非常差的结果到优秀的结果)。然后使用广义有序逻辑回归分析 9 个参数(编码为哑变量)对术后 Oswestry 功能障碍指数改善的预测作用。

结果

在 9 个参数中,有 8 个被认为是显著的预测因子。压缩的放射学分级是最强的预测因子,其次是多发性神经病、肥胖、症状持续时间、步态自主、神经根缺陷、美国麻醉医师协会评分和手术水平。相比之下,既往腰椎手术与手术结果无关。

结论

我们的研究结果表明,手术的理想患者应具有以下术前特征:Schizas 分级 D、无周围多发性神经病表现、体重指数<30kg/m、症状持续时间<2 年、步态自主距离<100m、无神经根缺陷、狭窄程度为 1 个节段、美国麻醉医师协会评分为 1、2 或 3。

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