Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.
Department of Dermatology, Andrology and SITs, Ain Shams University Medical College, Cairo, Egypt.
Clin Dermatol. 2020 Nov-Dec;38(6):693-701. doi: 10.1016/j.clindermatol.2020.06.009. Epub 2020 Jun 26.
Drug-induced changes of hair and nails have been observed with a variety of different pharmaceutical agents, both topical and systemic. These compounds or their metabolites may interfere with hair cycling and texture, nail matrix, nail bed, nail folds, and microvasculature. Phototoxic reactions may also occur. Before initiating treatment, physicians and patients should be aware of possible adverse events to hair and nails and should be aware of the preventive measures, if available, as quality of life can be reduced, and adherence and compliance to treatment may be impaired.
药物可引起各种不同的药物制剂（包括局部用制剂和系统用制剂）诱导的毛发和指甲变化。这些化合物或其代谢产物可能会干扰毛发的循环和质地、甲母质、甲板、甲皱襞和微血管。光毒性反应也可能发生。在开始治疗之前，医生和患者应了解毛发和指甲可能出现的不良反应，并且应了解是否有预防措施，如果有，因为生活质量可能会降低，并且对治疗的依从性和顺应性可能会受到损害。
