血浆钴水平与 2 型糖尿病之间的 U 型关联。

U-shaped association between plasma cobalt levels and type 2 diabetes.

机构信息

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Chemosphere. 2021 Mar;267:129224. doi: 10.1016/j.chemosphere.2020.129224. Epub 2020 Dec 13.

DOI:10.1016/j.chemosphere.2020.129224

PMID:33341733

Abstract

AIMS

We aimed to investigate the association of plasma cobalt with newly diagnosed type 2 diabetes (T2D) and further explore the potential interaction effects between cobalt and several redox metals, such as manganese, copper and selenium.

DESIGN

A large case-control study including 4564 subjects was conducted. 2282 cases with newly diagnosed T2D and 2282 controls were matched by sex and age. The concentrations of cobalt and other metals in plasma were detected with inductively coupled plasma mass spectrometry (ICPMS).

RESULTS

The medians of the cobalt concentrations in plasma were 1.68 μg/dL for controls and T2D. There was a U-shaped relation between T2D and plasma cobalt, which was categorized into quartiles. After multivariable adjusted for the confounding factors, the odds ratios (ORs) of T2D across quartiles were 1.22 (95% CI: 1.01, 1.46), 1.12 (95% CI: 0.94, 1.35), 1.00 (reference) and 1.46 (95% CI: 1.22, 1.75), respectively. The association was almost consistent in subgroup analyses. According to the restricted cubic spline analysis, the lowest ORs of T2D was observed at the plasma cobalt of 2.00 μg/dL. There was a significant interaction between plasma cobalt and copper (P < 0.01). The ORs of T2D in those with medium concentration of plasma cobalt and copper was the lowest.

CONCLUSIONS

Higher or lower concentrations of plasma cobalt were related to higher ORs of T2D. The inter-relationship among redox metals in T2D should be further investigated.

摘要

目的

我们旨在研究血浆钴与新诊断的 2 型糖尿病（T2D）之间的关联，并进一步探讨钴与锰、铜和硒等几种氧化还原金属之间的潜在相互作用效应。

设计

进行了一项包括 4564 名受试者的大型病例对照研究。2282 例新诊断的 T2D 患者和 2282 例对照者按性别和年龄匹配。采用电感耦合等离子体质谱法（ICPMS）检测血浆中钴和其他金属的浓度。

结果

对照组和 T2D 组血浆钴浓度的中位数分别为 1.68μg/dL。T2D 与血浆钴之间呈 U 型关系，分为四分位。经多变量调整混杂因素后，四分位组 T2D 的比值比（OR）分别为 1.22（95%可信区间：1.01，1.46）、1.12（95%可信区间：0.94，1.35）、1.00（参考）和 1.46（95%可信区间：1.22，1.75）。亚组分析结果基本一致。根据限制立方样条分析，T2D 的最低 OR 出现在血浆钴为 2.00μg/dL 时。钴与铜之间存在显著的交互作用（P<0.01）。血浆钴和铜浓度中等的 T2D 患者的 OR 最低。